Candida albicans specializations for iron homeostasis: from commensalism to virulence.

Candida albicans specializations for iron homeostasis: from commensalism to virulence.
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DOI:
10.1016/j.mib.2013.09.006
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发表时间:
2013-12
影响因子:
5.4
通讯作者:
Noble, Suzanne M.
Noble, Suzanne M.
中科院分区:
生物学2区
文献类型:
--
作者:
Noble, Suzanne M.

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Candida albicans is a fungal commensal-pathogen that persistently associates with its mammalian hosts. Between the commensal and pathogenic lifestyles, this microorganism inhabits host niches that differ markedly in the levels of bioavailable iron. A number of recent studies have exposed C. albicans specializations for acquiring iron from specific host molecules in regions where iron is scarce, while also defending against iron-related toxicity in regions where iron occurs in surfeit. Together, these results point to a central role for iron homeostasis in the evolution of this important human pathogen.
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