Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week.
Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis: JACC Review Topic of the Week.
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DOI：
10.1016/j.jacc.2020.11.031
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发表时间：
2021-01-26
影响因子：
24
通讯作者：
Finn AV
中科院分区：
文献类型：
--
作者：
Kawakami R;Sakamoto A;Kawai K;Gianatti A;Pellegrini D;Nasr A;Kutys B;Guo L;Cornelissen A;Mori M;Sato Y;Pescetelli I;Brivio M;Romero M;Guagliumi G;Virmani R;Finn AV
为了探讨严重急性呼吸综合征-冠状病毒-2（SARS-CoV-2）引起的心肌炎是否构成心脏损伤的重要机制，对已发表的资料进行了综述，并增加了作者从16例死于SARS-CoV-2感染的患者尸检中获得的经验。心肌炎是一种罕见的病理诊断发生在4.5%的高度选择的情况下进行尸检或心肌内膜活检。尽管在我们自己的尸检登记中，大多数2019冠状病毒病（COVID-19）感染受试者的肺部都可以发现聚合酶链反应可检测到的病毒，但只有2例在心脏中检测到病毒。应该认识到，在非感染性死亡和COVID-19病例中可以看到单独由巨噬细胞和T细胞引起的心肌炎症，但两者的程度不同，并且在任何情况下，这些发现都不代表临床相关的心肌炎。鉴于其极低的频率和不明确的治疗意义，作者不主张在COVID-19背景下使用肌内膜活检来诊断心肌炎。
To investigate whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)–induced myocarditis constitutes an important mechanism of cardiac injury, a review was conducted of the published data and the authors’ experience was added from autopsy examination of 16 patients dying of SARS-CoV-2 infection. Myocarditis is an uncommon pathologic diagnosis occurring in 4.5% of highly selected cases undergoing autopsy or endomyocardial biopsy. Although polymerase chain reaction–detectable virus could be found in the lungs of most coronavirus disease-2019 (COVID-19)–infected subjects in our own autopsy registry, in only 2 cases was the virus detected in the heart. It should be appreciated that myocardial inflammation alone by macrophages and T cells can be seen in noninfectious deaths and COVID-19 cases, but the extent of each is different, and in neither case do such findings represent clinically relevant myocarditis. Given its extremely low frequency and unclear therapeutic implications, the authors do not advocate use of endomyocardial biopsy to diagnose myocarditis in the setting of COVID-19.
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影响因子：
24
作者：
Puntmann, Valentina O.;Carerj, M. Ludovica;Nagel, Eike
通讯作者：
Nagel, Eike
DOI：
10.1016/j.carpath.2020.107300
发表时间：
2021-01
期刊：
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
影响因子：
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作者：
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通讯作者：
Vander Heide RS
影响因子：
15.1
作者：
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通讯作者：
Reynolds, Harmony R.
影响因子：
168.9
作者：
Bradley, Benjamin T.;Maioli, Heather;Marshall, Desiree A.
通讯作者：
Marshall, Desiree A.
影响因子：
39.3
作者：
Dennert R;Crijns HJ;Heymans S
通讯作者：
Heymans S