Autophagic fungal cell death is necessary for infection by the rice blast fungus
Autophagic fungal cell death is necessary for infection by the rice blast fungus
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DOI：
10.1126/science.1124550
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发表时间：
2006-04-28
期刊：
影响因子：
56.9
通讯作者：
Talbot, NJ
中科院分区：
文献类型：
--
作者：
Veneault-Fourrey, C;Barooah, M;Talbot, NJ
稻瘟病是由真菌稻瘟菌引起的，这种真菌会产生称为附着细胞的特殊感染细胞，以穿透水稻坚韧的外角质层。我们发现，附着胞的形成需要依次完成有丝分裂、核迁移和感染起源的分生孢子（真菌孢子）的死亡。有丝分裂期间的遗传干预阻止了附着胞发育和分生孢子死亡。 MgATG8 基因的靶向突变导致自噬受损，阻止了分生孢子细胞死亡，但使真菌变得非致病性。因此，稻瘟病的发生需要分生孢子的自噬细胞死亡。
Rice blast is caused by the fungus Magnaporthe grisea, which elaborates specialized infection cells called appressoria to penetrate the tough outer cuticle of the rice plant Oryza sativa. We found that the formation of an appressorium required, sequentially, the completion of mitosis, nuclear migration, and death of the conidium (fungal spore) from which the infection originated. Genetic intervention during mitosis prevented both appressorium development and conidium death. Impairment of autophagy, by the targeted mutation of the MgATG8 gene, arrested conidial cell death but rendered the fungus nonpathogenic. Thus, the initiation of rice blast requires autophagic cell death of the conidium.