Effect of Ferulic Acid Isolated from Cnidium Officinale on the Synthesis of Hyaluronic Acid
Effect of Ferulic Acid Isolated from Cnidium Officinale on the Synthesis of Hyaluronic Acid
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蛇床子阿魏酸对透明质酸合成的影响
DOI：
10.15230/scsk.2013.39.4.281
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Sang Hwa Lee
中科院分区：
文献类型：
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作者：
Hye Jin Song;Mu Hyun Jin;Sang Hwa Lee
透明质酸（HA）是皮肤中主要的细胞外基质成分之一。随着年龄的增长，HA含量逐渐下降，这可能是导致皮肤水分减少、皱纹形成和皮肤弹性下降的原因。HA合成酶基因家族（HAS-1，2，3）中，HAS-2在人皮肤成纤维细胞HA合成的调控中起重要作用。本研究旨在阐明蛇床子中提取的阿魏酸对透明质酸合成的影响。半定量RT-PCR和实时荧光定量PCR结果显示阿魏酸可增加人皮肤成纤维细胞HAS-2基因的mRNA水平，ELISA结果显示阿魏酸可增加人皮肤成纤维细胞HA的合成。我们的研究表明，阿魏酸可以防止皮肤老化，如皱纹，干燥和弹性下降，所有这些都可以归因于人体皮肤中HA含量的减少。
Hyaluronic acid (HA) is one of the major extracellular matrix components in skin. The HA content is reportedto decline with age, which may contribute to decrease in skin moisture, wrinkle formation and the decrease in elasticityof the skin. Among the family of HA synthase genes (HAS-1, 2, 3) identified so far, HAS-2 plays crucial roles inthe regulation of HA synthesis in human skin fibroblasts. In this study, we elucidated the effects of ferulic acid isolatedfrom Cnidium officinale on HA production. Semi-quantitative RT-PCR and quantitative real-time PCR showed that ferulicacid increased mRNA level of HAS-2 gene and ELISA assay also revealed that ferulic acid increased HA productionin human skin fibroblasts. Our study suggests that ferulic acid might prevent age-dependent skin deteriorations suchas wrinkles, dryness and elasticity decrease, all of which could be ascribed to the reduction of the HA content in humanskin.