MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-like 1 (FGFRL1)
MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-like 1 (FGFRL1)
复制标题
DOI：
10.1074/jbc.m110.170852
复制
发表时间：
2011-01-07
影响因子：
4.8
通讯作者：
Tsujimoto, Gozoh
中科院分区：
文献类型：
--
作者：
Tsuchiya, Soken;Fujiwara, Takeshi;Tsujimoto, Gozoh
microRNA (miRNA) 在人类恶性肿瘤中的重要性已得到充分认识。在此，我们报道 microRNA-210 (miR-210) 的表达在人食管鳞状细胞癌及其衍生细胞系中下调。观察到 miR-210 水平显着降低，尤其是在低分化癌中。我们发现miR-210通过诱导细胞死亡和G(1)/G(0)和G(2)/M细胞周期停滞来抑制癌细胞存活和增殖。最后，我们确定成纤维细胞生长因子受体样 1 (FGFRL1) 是食管鳞状细胞癌中 miR-210 的靶标，并证明 FGFRL1 通过防止细胞周期停滞在 G1/G0 来加速癌细胞增殖。综上所述，我们的研究结果表明 miR-210 作为一种肿瘤抑制性 microRNA，对癌细胞增殖具有重要作用。
The importance of microRNAs (miRNAs) in human malignancies has been well recognized. Here, we report that the expression of microRNA-210 (miR-210) is down-regulated in human esophageal squamous cell carcinoma and derived cell lines. Marked decreases in the level of miR-210 were observed especially in poorly differentiated carcinomas. We found that miR-210 inhibits cancer cell survival and proliferation by inducing cell death and cell cycle arrest in G(1)/G(0) and G(2)/M. Finally, we identified fibroblast growth factor receptor-like 1 (FGFRL1) as a target of miR-210 in esophageal squamous cell carcinoma and demonstrated that FGFRL1 accelerates cancer cell proliferation by preventing cell cycle arrest in G1/G0. Taken together, our findings show an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation.