Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults
Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults
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DOI：
10.1007/s00394-010-0165-0
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发表时间：
2011-10-01
影响因子：
5
通讯作者：
Tamura, Tsunenobu
中科院分区：
文献类型：
--
作者：
Nakazato, Mio;Maeda, Takahiro;Tamura, Tsunenobu
目的血浆叶酸浓度与体重指数(BMI，kg/m(2))呈负相关，尽管这些发现存在争议。方法测定434名健康成人(343名女性和91名男性)血浆和红细胞叶酸及血浆总同型半胱氨酸(THcy)浓度。结果血浆、红细胞叶酸和tHcy的平均值分别为21.6nmol/L、844(+/-291)nmol/L和11.6(+/-3.9)mmoL/L。平均BMI为22.8(+/-3.0；15.6~33.3)kg/m(2)，只有72人(17%)的BMI为26.0 kg/m(2)。平均血浆叶酸随着BMI的增加而降低(p趋势和t；0.01)，而无论BMI如何，平均红细胞叶酸和血浆tHcy相似(p趋势分别为0.49和0.28)。结论BMI对叶酸营养状况的解释较为复杂，但对血浆叶酸的影响相对较小。在为未来的大规模研究选择对象时，重要的是要考虑到这种联系。应该研究体重指数和血浆叶酸浓度之间的这种负相关的机制。
Purpose Plasma folate concentrations are suggested to be negatively associated with body mass index (BMI, kg/m(2)), although these findings are controversial. Our objective was to evaluate the association of BMI with blood folate and total homocysteine (tHcy) concentrations.Methods We measured plasma and erythrocyte folate and plasma tHcy concentrations in 434 healthy adults (343 women and 91 men; mean age of 63.8 +/- A 10.7 [SD, range 23-88] years), who participated in a 2007 population-based survey in western Japan.Results The overall mean plasma and erythrocyte folate and tHcy were 21.6 (+/- 11.0, SD) nmol/L, 844 (+/- 291) nmol/L and 11.6 (+/- 3.9) mu mol/L, respectively. The mean BMI was 22.8 (+/- 3.0; 15.6-33.3) kg/m(2), and only 72 subjects (17%) had BMI > 26.0 kg/m(2). Mean plasma folate decreased as BMI increased (p-trend < 0.01), whereas mean erythrocyte folate and plasma tHcy were similar regardless of BMI (p-trends = 0.49 and 0.28, respectively).Conclusion Our data indicate that the interpretation of plasma folate concentrations to assess folate nutritional status is complicated by BMI, although the impact of BMI on plasma folate was relatively small. It is important to take this association into account for the selection of subjects for future large-scale studies. The mechanism of this inverse association between BMI and plasma folate concentrations should be investigated.