FeCl3-catalyzed nucleophilic substitution of propargylic acetates with enoxysilanes.
FeCl3-catalyzed nucleophilic substitution of propargylic acetates with enoxysilanes.
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DOI：
10.1021/jo701782g
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发表时间：
2007-11
期刊：
影响因子：
--
通讯作者：
Zhuang-Ping Zhan;Xu-bin Cai;Shaopeng Wang;Jingxun Yu;Hui-juan Liu;Yuancun Cui
中科院分区：
文献类型：
--
作者：
Zhuang-Ping Zhan;Xu-bin Cai;Shaopeng Wang;Jingxun Yu;Hui-juan Liu;Yuancun Cui
An efficient FeCl3-catalyzed substitution reaction of propargylic acetates with enoxysilanes under mild conditions to afford corresponding gamma-alkynyl ketones has been developed. The substitution reaction is followed by a TsOH-catalyzed cyclization without purification of the gamma-alkynyl ketone intermediates, offering a straightforward synthetic route to tri- or tetrasubstituted furans.
