Epidemiology and prevalence of hyperuricemia among men and women in Chinese rural population: The Henan Rural Cohort Study
Epidemiology and prevalence of hyperuricemia among men and women in Chinese rural population: The Henan Rural Cohort Study
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DOI：
10.1080/14397595.2019.1660048
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发表时间：
2019-09-10
影响因子：
2.2
通讯作者：
Wang, Chongjian
中科院分区：
文献类型：
--
作者：
Dong, Xiaokang;Zhang, Honglei;Wang, Chongjian
目的：探讨中国农村人群高尿酸血症的最新患病情况及影响因素。方法：于2015年7月至2017年9月进行调查，从河南农村队列研究中总共招募了38,855名受试者（男性15,371名，女性23,484名）。高尿酸血症定义为男性血清尿酸水平> 7.0 mg/dL，女性> 6.0 mg/dL。对 19 项关注高尿酸血症患病率的研究进行荟萃分析，以验证横断面调查的结果。结果：高尿酸血症粗患病率和年龄标化患病率分别为10.24%和12.60%。随着年龄的增长，男性高尿酸血症的患病率下降，但女性却出现相反的趋势。荟萃分析结果显示，中国农村地区高尿酸血症患病率为11.7%，与当前调查结果一致。多变量逻辑回归显示，超重或肥胖、高胆固醇血症、高甘油三酯血症、低α脂蛋白血症和高血清肌酐水平可能增加高尿酸血症的风险，而高体力活动和空腹血糖与所有参与者的高尿酸血症风险较低相关。结论：我国农村地区最新高尿酸血症患病率较高，且与多种因素相关，迫切需要制定高尿酸血症防治策略。
Objective: The aim of this study was to explore the latest prevalence of hyperuricemia and influencing factors in Chinese rural population. Methods: A survey was conducted from July 2015 to September 2017. A total of 38,855 (15,371 men and 23,484 women) subjects were recruited from the Henan Rural Cohort Study. Hyperuricemia was defined as a serum urate level of >7.0 mg/dL for men and >6.0 mg/dL for women. A meta-analysis of 19 studies that focused on hyperuricemia prevalence was performed to validate the result of the cross-sectional survey. Results: The crude and age-standardized prevalence of hyperuricemia was 10.24% and 12.60%, respectively. The prevalence of hyperuricemia decreased in men with increasing age, but the opposite trend was observed in women. The results of meta-analysis demonstrated that hyperuricemia prevalence in Chinese rural areas was 11.7%, consistent with the result of current survey. Multivariate logistic regression revealed that overweight or obesity, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia and high serum creatinine level could increase the risk of hyperuricemia, while high physical activity and fasting plasma glucose were associated with a lower risk of hyperuricemia in all participants. Conclusion: The latest prevalence of hyperuricemia is high in rural China and is associated with multiple factors, indicating that prevention and control strategies for hyperuricemia are needed urgently.