Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States.
Incidence of carcinoma of the major salivary glands according to the WHO classification, 1992 to 2006: a population-based study in the United States.
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DOI：
10.1158/1055-9965.epi-09-0638
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Dores GM
中科院分区：
文献类型：
--
作者：
Boukheris H;Curtis RE;Land CE;Dores GM
大唾液腺癌（M-SGC）由一组形态多样、病因不明的罕见肿瘤组成。为了深入了解病因，我们利用世界卫生组织分类方案 (WHO-2005) 评估了 M-SGC 的发病率。我们计算了 1992 年至 2006 年监测、流行病学和最终结果计划中诊断的 M-SGC 的年龄调整发病率 (IR) 和 IR 比率 (IRR)。总体而言，1992 年至 2006 年间诊断出 6,391 例 M-SGC（IR=11.95/1,000,000 人年）。近 85% 的病例（n=5,370；IR=10.00）包含在 WHO-2005 范围内，其中男性的 IR 高于女性（IRR=1.51，95%CI=1.43–1.60）。鳞状细胞癌 (IR=3.44) 和粘液表皮样癌 (IR=3.23) 在男性中最常见，而粘液表皮样癌 (IR=2.67)、腺泡细胞癌 (IR=1.57) 和腺样囊性癌 (IR=1.40) 在女性中最常见。粘液表皮样癌、腺泡细胞癌和腺样囊性癌在 50 岁左右的女性中占主导地位；此后，女性和男性中腺泡细胞癌和腺样囊性癌的IR几乎相等，而男性中粘液表皮样癌的IR超过女性中的IR（IRR=1.57；95%CI=1.38-1.78）。除粘液表皮样癌和腺样囊性癌在所有种族中发生率相同外，其他亚型在黑人和亚洲/太平洋岛民中的发病率显着低于白人。腺样囊性癌在下颌下腺和腮腺中的发生率相同，评估的其他 M-SGC 在下颌下腺中的 IR 较低 77-98%。 1992 年至 2006 年期间，总体 M-SGC IR 保持稳定。根据组织学亚型的不同发病模式表明，M-SGC 是一组多样化的肿瘤，其特征是病因和/或生物学异质性，且易感性因性别和种族而异。
Carcinomas of the major salivary glands (M-SGC) comprise a morphologically diverse group of rare tumors of largely unknown cause. To gain insight into etiology, we evaluated incidence of M-SGC utilizing the World Health Organization classification schema (WHO-2005). We calculated age-adjusted incidence rates (IRs) and IR ratios (IRRs) for M-SGC diagnosed between 1992–2006 in the Surveillance, Epidemiology and End Results Program. Overall, 6,391 M-SGCs (IR=11.95/1,000,000 person-years) were diagnosed during 1992–2006. Nearly 85% of cases (n=5,370; IR=10.00) were encompassed within WHO-2005 and among these, males had higher IRs than females (IRR=1.51, 95%CI=1.43–1.60). Squamous cell (IR=3.44) and mucoepidermoid (IR=3.23) carcinomas occurred most frequently among males, whereas, mucoepidermoid (IR=2.67), acinic cell (IR=1.57), and adenoid cystic (IR=1.40) carcinomas were most common among females. Mucoepidermoid, acinic cell, and adenoid cystic carcinomas predominated in females through approximately age 50 years; thereafter IRs of acinic cell and adenoid cystic carcinomas were nearly equal among females and males, whereas IRs of mucoepidermoid carcinoma among males exceeded IRs among females (IRR=1.57; 95%CI=1.38–1.78). Except for mucoepidermoid and adenoid cystic carcinomas which occurred equally among all races, other subtypes had significantly lower incidence among Blacks and Asian/Pacific Islanders than among Whites. Adenoid cystic carcinoma occurred equally in the submandibular and parotid glands, and other M-SGCs evaluated had 77–98% lower IRs in the submandibular gland. Overall M-SGC IRs remained stable during 1992–2006. Distinct incidence patterns according to histologic subtype suggest that M-SGCs are a diverse group of neoplasms characterized by etiologic and/or biologic heterogeneity with varying susceptibility by gender and race.