Serum hepatocyte growth factor levels and the effects of antidepressants in panic disorder
Serum hepatocyte growth factor levels and the effects of antidepressants in panic disorder
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DOI：
10.1016/j.npep.2010.04.007
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发表时间：
2010-10-01
期刊：
影响因子：
2.9
通讯作者：
Akiyoshi, Jotaro
中科院分区：
文献类型：
--
作者：
Kanehisa, Masayuki;Ishitobi, Yoshinobu;Akiyoshi, Jotaro
先前的动物研究表明，肝细胞生长因子（HGF）可能与抑郁和焦虑相关的行为有关。我们的目的是将血清HGF水平与惊恐障碍（伴或不伴广场恐怖症）患者和健康对照者的状态-特质焦虑量表（STAI）、情绪状态谱（POMS）和NEO- pi - r评分联系起来。我们检查了67例惊恐障碍患者和97例对照。根据患者的测试成绩是否改善50%（好/高反应组：n = 26）或没有（差/低反应组：n = 41），将患者分为两组。在健康对照和惊恐障碍个体中，血清HGF水平与STAI或NEO-PI-R评分之间没有显著关联。然而，在POMS测试评分中，健康对照者血清HGF水平与疲劳之间存在显著相关。良好/高反应组HGF浓度较低/差反应组和对照组均显著升高（p < 0.01）。不良反应组的HGF水平与对照组没有差异（p = 0.48）。这些结果表明，血清HGF水平升高可能是惊恐障碍患者抗抑郁疗效的必要条件。英国皇家版权所有(C) 2010出版的爱思唯尔有限公司版权所有。
Previous animal studies have suggested that hepatocyte growth factor (HGF) could be associated with depression- and anxiety-related behaviors. Our aim was to relate serum HGF levels with State-Trait Anxiety Inventory (STAI), Profile of Mood State (POMS), and Revised NEO Personality Inventory (NEO-PI-R) scores in patients with panic disorder (with or without agoraphobia) and healthy controls. We examined 67 patients with panic disorders and 97 controls. Patients were split into two groups according to whether they exhibited a 50% improvement in test scores (good/high response group: n = 26) or not (poor/low response group: n = 41). In both healthy control and panic disorder individuals, there were no significant associations between HGF serum levels and STAI or NEO-PI-R scores. However, there was a significant correlation between serum HGF levels and fatigue in healthy control subjects in as scored by POMS testing. HGF concentration in the good/high response group was significantly elevated compared to both the low/poor response group (p < 0.01) and the control group (p < 0.01). HGF levels in the poor response group did not differ from the control group (p = 0.48). These results indicate that increased serum HGF levels might be a requirement for antidepressant efficacy in patients with panic disorders. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.