Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
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作者：
To identify susceptibility loci for ankylosing spondylitis, we undertook a genome-wide association study in 2,053 unrelated ankylosing spondylitis cases among people of European descent and 5,140 ethnically matched controls, with replication in an independent cohort of 898 ankylosing spondylitis cases and 1,518 controls. Cases were genotyped with Illumina HumHap370 genotyping chips. In addition to strong association with the major histocompatibility complex (MHC; P < 10−800), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 × 10−19) and 21q22 (rs2242944; P = 8.3 × 10−20), as well as in the genes ANTXR2 (rs4333130; P = 9.3 × 10−8) and IL1R2 (rs2310173; P = 4.8 × 10−7). We also replicated previously reported associations at IL23R (rs11209026; P = 9.1 × 10−14) and ERAP1 (rs27434; P = 5.3 × 10−12). This study reports four genetic loci associated with ankylosing spondylitis risk and identifies a major role for the interleukin (IL)-23 and IL-1 cytokine pathways in disease susceptibility.
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Osterix周围地区的常见变体与骨矿物质密度和儿童期生长有关。
影响因子：
3.5
作者：
Timpson NJ;Tobias JH;Richards JB;Soranzo N;Duncan EL;Sims AM;Whittaker P;Kumanduri V;Zhai G;Glaser B;Eisman J;Jones G;Nicholson G;Prince R;Seeman E;Spector TD;Brown MA;Peltonen L;Smith GD;Deloukas P;Evans DM
通讯作者：
Evans DM
DOI：
10.1084/jem.20070906
发表时间：
2008-02-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Armaka M;Apostolaki M;Jacques P;Kontoyiannis DL;Elewaut D;Kollias G
通讯作者：
Kollias G
影响因子：
30.8
作者：
Kugathasan, Subra;Baldassano, Robert N.;Bradfield, Jonathan P.;Sleiman, Patrick M. A.;Imielinski, Marcin;Guthery, Stephen L.;Cucchiara, Salvatore;Kim, Cecilia E.;Frackelton, Edward C.;Annaiah, Kiran;Glessner, Joseph T.;Santa, Erin;Willson, Tara;Eckert, Andrew W.;Bonkowski, Erin;Shaner, Julie L.;Smith, Ryan M.;Otieno, F. George;Peterson, Nicholas;Abrams, Debra J.;Chiavacci, Rosetta M.;Grundmeier, Robert;Mamula, Petar;Tomer, Gitit;Piccoli, David A.;Monos, Dimitri S.;Annese, Vito;Denson, Lee A.;Grant, Struan F. A.;Hakonarson, Hakon
通讯作者：
Hakonarson, Hakon
影响因子：
4.9
作者：
Lappalainen, Maarit;Halme, Leena;Paavola-Sakki, Paulina
通讯作者：
Paavola-Sakki, Paulina
影响因子：
9.8
作者：
Waschke, KA;Villani, AC;Wild, GE
通讯作者：
Wild, GE