ANTIBODIES TO EPSTEIN-BARR VIRUS CAPSID ANTIGEN AND EARLY ANTIGEN IN NASOPHARYNGEAL CARCINOMA AND COMPARISON GROUPS
ANTIBODIES TO EPSTEIN-BARR VIRUS CAPSID ANTIGEN AND EARLY ANTIGEN IN NASOPHARYNGEAL CARCINOMA AND COMPARISON GROUPS
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DOI：
10.1093/oxfordjournals.aje.a112470
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发表时间：
1977-01-01
影响因子：
5
通讯作者：
HIRAYAMA, T
中科院分区：
文献类型：
--
作者：
LIN, TM;YANG, CS;HIRAYAMA, T
对263例鼻咽癌患者、624名年龄和性别匹配的邻居对照、570名鼻咽癌患者家属和830名邻居对照家属进行了EB病毒衣壳抗原（抗VCA）和早期抗原（抗EA）抗体检测。抗体滴度分布在鼻咽癌组与其他3组之间差异有统计学意义。超过55%和45%的NPC患者的滴度为≥1：640和≥抗-VCA和抗-EA的滴度分别为1：80，而其他3组中具有如此高滴度的分别为< 6.7%和2.5%。NPC患者抗VCA和抗EA滴度的几何平均值分别为1：352和1：45，而对照组分别为< 1：77和1：12。抗VCA和抗EA滴度显著相关。本文还讨论了EB病毒与鼻咽癌的关系。
Antibodies to Epstein-Barr virus capsid antigen (anti-VCA) and early antigen (anti-EA) were measured in 263 patients with nasopharyngeal carcinoma (NPC), 624 age- and sex-matched neighborhood controls, 570 family members of NPC patients and 830 family members of neighborhood controls in Taiwan. The distribution of antibody titers was significantly different between NPC patients and the other 3 groups. More than 55 and 45% of NPC patients had titers of .gtoreq. 1:640 and .gtoreq. 1:80 for anti-VCA and anti-EA, respectively, while < 6.7% and 2.5% of the other 3 groups had such high titers. The geometric means of anti-VCA and anti-EA titers were 1:352 and 1:45, respectively, in NPC patients compared to < 1:77 and 1:12, respectively, in the comparison groups. Anti-VCA and anti-EA titers were significantly correlated. The association of EBV with NPC is discussed.