Entomological survey and report of a knockdown resistance mutation in the malaria vector Anopheles gambiae from the Republic of Guinea
Entomological survey and report of a knockdown resistance mutation in the malaria vector Anopheles gambiae from the Republic of Guinea
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DOI：
10.1016/j.trstmh.2010.02.002
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发表时间：
2010-07-01
影响因子：
2.2
通讯作者：
Manguin, S.
中科院分区：
文献类型：
--
作者：
Carnevale, P.;Toto, J. C.;Manguin, S.
我们的昆虫学调查的目的是在几内亚东南部疟疾传播率高的矿区的四个研究地点估计按蚊物种的蚊子生物多样性、感染率和杀虫剂抗性水平。(77%）是最常见的按蚊，其次是按蚊。funestus（20%）。的标本。冈比亚复合体以An为主。冈比亚按蚊S型（97.6%），占1.4%。冈比亚M型仅在Kerouane中发现，而An.在所有四个研究地点都存在的arabiensis。冈比亚按蚊S型和安.感染率分别为4.1%和4.4%，接种率分别为0.60和0.19感染口/人/夜。此外，高水平（79%）的敲低抗性（kdr）L1014 F突变的报道，在人口的An。冈比亚S型。几内亚勘探地区疟疾传播率很高，需要实施长期病媒控制方案。然而，这样的控制方案将不得不考虑在显性载体中kdr基因的存在，其水平高得令人惊讶，这可能会降低载体控制的预期影响。(C)2010年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
The purpose of our entomological survey was to estimate mosquito biodiversity, infectivity rates and insecticide resistance levels in Anopheles species in four study sites in a mining area with high malaria transmission in southeastern Guinea.Anopheles gambiae s.l. (77%)was the most common Anopheles collected followed by An. funestus (20%). The specimens of the An. gambiae complex were predominantly An. gambiae S form (97.6%) with 1.4% of An. gambiae M form found in Kerouane only, and 1% of An. arabiensis which was present in all four study sites. Anopheles gambiae S form and An. funestus were found to be infected with Plasmodium falciparum, with infectivity rates of 4.1% and 4.4% and inoculation rates of 0.60 and 0.19 infected bite/person/night, respectively. In addition, a high level (79%) of the knockdown resistance (kdr) L1014F mutation was reported in the populations of An. gambiae S form. The high malaria transmission that occurs in the prospected area of Guinea requires a long-term vector control programme. However, such a control programme will have to consider the presence of the kdr gene at a surprisingly high level within the dominant vector, which could reduce the expected impact of vector control. (C) 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.