Serum γ-glutamyltransferase level is associated with periodontal disease independent of drinking habits in Japanese adults.
Serum γ-glutamyltransferase level is associated with periodontal disease independent of drinking habits in Japanese adults.
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DOI：
10.12659/msm.891204
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发表时间：
2014-10-31
期刊：
影响因子：
--
通讯作者：
Maeno M
中科院分区：
文献类型：
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作者：
Morita T;Yamazaki Y;Fujiharu C;Ishii T;Seto M;Nishinoue N;Sasaki Y;Kawato T;Motohashi M;Maeno M
非酒精性脂肪肝被认为是代谢综合征的肝脏表现。牙周病是一种具有全身性影响的轻度慢性炎症性疾病，许多研究表明代谢综合征与牙周炎之间存在相关性。在本研究中，我们调查牙周炎和肝脏生化参数之间的关系，根据饮酒习惯，通过横断面研究的数据，从日本人的职业设置。研究对象为2012年接受牙科和医疗检查的1510名员工（1218名男性，292名女性，平均年龄50.4岁）。牙周袋的存在和肝脏生化指标的血清水平之间的关联进行了评估。丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）水平在有牙周袋的受试者中高于无牙周袋的受试者。以GGT或ALT为因变量的多元Logistic回归分析（调整年龄、性别、吸烟和饮酒习惯以及代谢综合征的组成部分）显示，牙周袋与GGT（比值比，OR=1.48）显著相关，但与ALT无关。当根据有无饮酒习惯进行分析时，观察到类似的关联;无饮酒习惯的受试者（OR=1.84）的OR高于有饮酒习惯的受试者（OR=1.41）。在没有饮酒习惯的日本成年人中，牙周袋的存在与血清GGT（肝脏生化参数）水平相关，这表明牙周病与肝功能相关，与酒精摄入无关。
Non-alcoholic fatty liver disease is considered a hepatic manifestation of metabolic syndrome. Periodontal disease is a mild chronic inflammatory disease with systemic effects, and many studies have indicated an association between metabolic syndrome and periodontitis. In the present study, we investigated the relationship between periodontitis and liver biochemical parameters according to alcohol drinking habits through a cross-sectional study based on data from Japanese people in occupational settings. The subjects were 1510 employees (1218 males, 292 females, mean age 50.4 years) who underwent dental and medical checkups in 2012. Associations between the presence of periodontal pockets and serum levels of liver biochemical parameters were assessed. Alanine aminotransferase (ALT) and γ-glutamyltransferase (GGT) levels were higher in subjects with than without periodontal pockets. Multiple logistic regression analysis (adjusting for age, gender, cigarette smoking, and alcohol drinking habits, and components of metabolic syndrome) with GGT or ALT as the dependent variable revealed that there was a significant association between periodontal pockets and GGT (odds ratio, OR=1.48), but not ALT. Similar associations were observed when an analysis was performed according to the presence or absence of alcohol drinking habits; the OR was higher in subjects without (OR=1.84) than with drinking habits (OR=1.41). The presence of periodontal pockets was associated with serum levels of GGT, a liver biochemical parameter, in Japanese adults with no drinking habit, suggesting that periodontal disease is associated with liver function, independent of alcohol ingestion.