Ploidy regulation of gene expression
Ploidy regulation of gene expression
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DOI：
10.1126/science.285.5425.251
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发表时间：
1999-07-09
期刊：
影响因子：
56.9
通讯作者：
Fink, GR
中科院分区：
文献类型：
--
作者：
Galitski, T;Saldanha, AJ;Fink, GR
基于微阵列的基因表达分析发现，在从单倍体到四倍体的倍性变化的等基因酿酒酵母菌株中，存在倍性依赖表达的基因。这些基因的诱导或抑制与染色体组的数量成正比，与交配类型无关。某些G(1)周期蛋白的倍性依赖性抑制可以解释与高倍性相关的更大的细胞大小，并提示细胞周期进程的倍性依赖性修饰。此外，FLO11基因的倍性调控对酵母的发育有直接影响。
Microarray-based gene expression analysis identified genes showing ploidy-dependent expression in isogenic Saccharomyces cerevisiae strains that varied in ploidy from haploid to tetraploid. These genes were induced or repressed in proportion to the number of chromosome sets, regardless of the mating type. Ploidy-dependent repression of some G(1) cyclins can explain the greater cell size associated with higher ploidies, and suggests ploidy-dependent modifications of cell cycle progression. Moreover, ploidy regulation of the FLO11 gene had direct consequences for yeast development.