Devazepide increases food intake in male but not female Zucker rats.
Devazepide increases food intake in male but not female Zucker rats.
复制标题
德维西吡可增加雄性 Zucker 大鼠的食物摄入量，但不会增加雌性 Zucker 大鼠的食物摄入量。
DOI：
10.1016/0031-9384(96)83164-7
复制
发表时间：
1996
影响因子：
2.9
通讯作者：
Greenberg,D
中科院分区：
文献类型：
--
作者：
Strohmayer,AJ;Greenberg,D
遗传性肥胖Zucker大鼠（fa/fa）与瘦对照组（Fa/？）相比具有高吞噬性。这种暴食症的特征是食物量增加。胆囊收缩素（CCK）已被证明可以减少包括人类在内的许多物种的膳食量。在本研究中，我们调查的作用，内源性胆囊收缩素介导的男性和女性肥胖Zucker大鼠的摄食过多。用特异性拮抗剂devazepide阻断CCKA型受体，并测量试验餐量。雄性肥胖和瘦大鼠显著增加食物摄入后，devazepide。无论是肥胖还是瘦雌性大鼠显著增加食物摄入后，devazepide。这是第一次证明内源性CCK介导的饱腹感存在性别差异。这些结果对女性饮食失调的发病率较高有影响。
The genetically obese Zucker rat (fa/fa) is hyperphagic compared to lean controls (Fa/?). This hyperphagia is characterized by increased meal size. Cholecystokinin (CCK) has been shown to decrease meal size in many species including humans. In the present study we investigated the role of endogenous CCK in mediating the hyperphagia of male and female obese Zucker rats. CCKA-type receptors were blocked with the specific antagonist, devazepide, and test meal size was measured. Male obese and lean rats significantly increased food intake following devazepide. Neither obese nor lean female rats significantly increased food intake following devazepide. This is the first demonstration of a gender difference in endogenous CCK-mediated satiety. These results have implications for the higher incidence of eating disorders in females.