Preliminary studies on the chemical characterization and antihyperlipidemic activity of polysaccharide from the brown alga Sargassum fusiforme
Preliminary studies on the chemical characterization and antihyperlipidemic activity of polysaccharide from the brown alga Sargassum fusiforme
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DOI：
10.1023/b:hydr.0000020335.46431.ad
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发表时间：
2004-01-15
期刊：
影响因子：
2.6
通讯作者：
Xing, HT
中科院分区：
文献类型：
--
作者：
Mao, WJ;Li, BF;Xing, HT
从褐藻羊栖菜(Sargassum fusiforme(Harv.)塞奇。经DEAE-Sephadex A50和Sephadex G-100柱层析纯化。纸层析(PC)、电泳和红外光谱(IR)研究表明，SFP是一种分子质量为16000的海藻酸盐，甘露糖酸(M)与古龙酸(G)的摩尔比为2.75.药理实验表明，四逆散能显著降低实验性高脂血症大鼠血清总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)的含量，显著升高高密度脂蛋白胆固醇(HDLC)的水平。
A polysaccharide (SFP) extracted from the brown alga Sargassum fusiforme (Harv.) Setch. was purified by chromatography on DEAE-Sephadex A50 and Sephadex G-100. Studies using paper chromatography (PC), electrophoresis and infrared spectroscopy (IR) indicated that SFP was a kind of alginate with a molecular weight of 16000 and a molar ratio of mannuronic acid (M) to guluronic acid (G) of 2.75. Pharmacological experiments showed that SFP could markedly decrease the content of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) in the serum of experimental hyperlipidemic rats, and significantly increase the level of high density lipoprotein-cholesterol (HDL-C).