INDEPENDENT RISK-FACTORS FOR ATRIAL-FIBRILLATION IN A POPULATION-BASED COHORT - THE FRAMINGHAM HEART-STUDY
INDEPENDENT RISK-FACTORS FOR ATRIAL-FIBRILLATION IN A POPULATION-BASED COHORT - THE FRAMINGHAM HEART-STUDY
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DOI：
10.1001/jama.1994.03510350050036
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发表时间：
1994-03-16
影响因子：
120.7
通讯作者：
WOLF, PA
中科院分区：
文献类型：
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作者：
BENJAMIN, EJ;LEVY, D;WOLF, PA
客观。-确定房颤的独立危险因素。设计。-队列研究。设定。-心脏脆弱性研究实验对象。原始队列中共有2090名男性和2641名女性成员，无心房颤动病史，年龄在55至94岁之间。主要结果指标。-性别特异性多元逻辑回归模型可识别房颤的独立风险因素，包括年龄、吸烟、糖尿病、心电图左心室肥大、高血压、心肌梗死、充血性心力衰竭和瓣膜疾病。结果。-在长达38年的随访中，264名男性和298名女性发生了房颤，在调整了年龄和其他房颤风险因素后，男性发生房颤的风险是女性的1.5倍。在全多变量模型中，年龄每增加10岁，房颤的比值比（OR）男性为2.1，女性为2.2（P
Objective.-To determine the independent risk factors for atrial fibrillation. Design.-Cohort study. Setting.-The Framingham Heart Study. Subjects.-A total of 2090 men and 2641 women members of the original cohort, free of a history of atrial fibrilltation, between the ages of 55 and 94 years. Main Outcome Measures.-Sex-specific multiple logistic regression models to identify independent risk factors for atrial fibrillation, including age, smoking, diabetes, electrocardiographic left ventricular hypertrophy, hypertension, myocardial infarction, congestive heart failure, and valve disease. Results.-During up to 38 years of follow-up, 264 men and 298 women developed atrial fibrillation, After adjusting for age and other risk factors for atrial fibrillation, men had a 1.5 times greater risk of developing atrial fibrillation than women. In the full multivariable model, the odds ratio (OR) of atrial fibrillation for each decade of advancing age was 2.1 for men and 2.2 for women (P