Angiotensin-converting enzyme I/D and α-adducin Gly460Trp polymorphisms -: From angiotensin-converting enzyme activity to cardiovascular outcome
Angiotensin-converting enzyme I/D and α-adducin Gly460Trp polymorphisms -: From angiotensin-converting enzyme activity to cardiovascular outcome
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DOI：
10.1161/hypertensionaha.106.085498
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发表时间：
2007-06-01
期刊：
影响因子：
8.3
通讯作者：
Staessen, Jan A.
中科院分区：
文献类型：
--
作者：
Li, Yan;Zagato, Laura;Staessen, Jan A.
血管紧张素转换酶（ACE） I/D和α -内收蛋白（ADD1） Gly460Trp多态性与心血管危险因素相关。在一项前瞻性群体研究和细胞模型中，我们研究了这两种多态性的联合效应。我们随机招募1287名白人受试者（女性50.0%，平均年龄55.9岁）。我们从登记和重复检查中获得结果（中位数为3）。在9.0年（中位数）期间，发生了178例致死性或非致死性心血管事件。在ADD1 Trp等位基因携带者中，与ACE DD和I相关的多变量校正风险比为：总死亡率1.72 (P = 0.007)，心血管死亡率2.35 (P = 0.02)，所有心血管事件2.02 (P = 0.005)，心力衰竭2.59 （P = 0.03）。相比之下，这些风险比在ADD1 GlyGly纯合子中没有达到显著性（0.08）
The angiotensin-converting enzyme (ACE) I/D and the alpha-adducin (ADD1) Gly460Trp polymorphisms are associated with cardiovascular risk factors. In a prospective population study and in cell models, we investigated the combined effects of these 2 polymorphisms. We randomly recruited 1287 white subjects (women: 50.0%; mean age: 55.9 years). We obtained outcomes from registries and repeat examinations (median 3). Over 9.0 years (median), 178 fatal or nonfatal cardiovascular events occurred. In ADD1 Trp allele carriers, the multivariate-adjusted hazard ratios associated with ACE DD versus I were 1.72 (P = 0.007) for total mortality, 2.35 (P = 0.02) for cardiovascular mortality, 2.02 (P = 0.005) for all cardiovascular events, and 2.59 (P = 0.03) for heart failure. In contrast, these hazard ratios did not reach significance in ADD1 GlyGly homozygotes (0.08