TCTP in development and cancer.
TCTP in development and cancer.
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DOI：
10.1155/2012/105203
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发表时间：
2012
影响因子：
3
通讯作者：
Gurdon JB
中科院分区：
文献类型：
--
作者：
Koziol MJ;Gurdon JB
肿瘤抑制蛋白（TCTP）在动物物种中高度保守。它在许多不同的组织中广泛表达。它参与调节许多基本过程，如细胞增殖和生长、凋亡、多能性和细胞周期。因此，它对正常发育至关重要，如果调控不当，可能导致癌症，这并不奇怪。本文概述了TCTP的各种功能，重点是开发。此外，我们还讨论了TCTP失调或突变可能导致癌症的可能途径。
The translationally controlled tumor protein (TCTP) is highly conserved among animal species. It is widely expressed in many different tissues. It is involved in regulating many fundamental processes, such as cell proliferation and growth, apoptosis, pluripotency, and the cell cycle. Hence, it is not surprising that it is essential for normal development and, if misregulated, can lead to cancer. Provided herein is an overview of the diverse functions of TCTP, with a focus on development. Furthermore, we discuss possible ways by which TCTP misregulation or mutation could result in cancer.