More Diversity Yields a Clearer Picture into the Architecture of the Protein Kinase Domain.

More Diversity Yields a Clearer Picture into the Architecture of the Protein Kinase Domain.
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更多的多样性让我们对蛋白激酶结构域的结构有了更清晰的了解。

DOI:
10.1016/j.cels.2018.10.002
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发表时间:
2018
期刊:
影响因子:
9.3
通讯作者:
Seeliger,MarkusA
Seeliger,MarkusA
中科院分区:
生物学1区
文献类型:
--
作者:
Seeliger,MarkusA

文献摘要

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共进化分析揭示了蛋白激酶结构域中的哪些氨基酸共同介导催化、调节和底物结合。
Co-evolution analysis reveals which amino acids within the protein kinase domain are working together to mediate catalysis, regulation, and substrate binding.