Enhancement of bone to polylactic acid plate bonding by carbonate apatite coating
Enhancement of bone to polylactic acid plate bonding by carbonate apatite coating
复制标题
DOI：
10.1016/j.ceramint.2021.06.252
复制
发表时间：
2021-06
影响因子：
5.2
通讯作者：
Cheng Zhang;Koichiro Hayashi;K. Ishikawa
中科院分区：
文献类型：
--
作者：
Cheng Zhang;Koichiro Hayashi;K. Ishikawa
聚乳酸（PLA）没有骨导电性，导致PLA种植体早期失效。为了避免这个问题，将聚乳酸包覆，而不是掺入磷酸钙，被认为是有效的。在本研究中，采用热熔结合的方法在PLA板上涂覆颗粒状碳酸盐磷灰石（CAp）， CAp是骨的无机成分。CAp- coating PLA （CAp/PLA）板和PLA的水接触角分别为0.7°±0.1°和90.3°±3.9°。因此，CAp涂层显著提高了PLA表面的润湿性。CAp/PLA和PLA的粗糙度（Ra）分别为11.7±2.2 μm和1.8±0.2 μm。CAp涂层包含~30 ~ 80 μm和~2 μm两种微孔类型。因此，CAp涂层为PLA板提供了粗糙的表面和微孔。将CAp/PLA和未涂覆PLA板固定在兔胫骨表面，评估其成骨和粘附能力。植入四周后，CAp/PLA板表面形成新骨。相比之下，在未涂覆的PLA板和胫骨之间的大部分区域没有组织存在。CAp/PLA和PLA板与胫骨的拉伸结合强度分别为4.0±2.5和0 N。因此，PLA的CAp涂层促进了钢板表面新骨的形成，增加了早期与骨表面结合的能力。PLA的CAp涂层是实现快速和坚固的骨固定的有效策略。
Polylactic acid (PLA) has no osteoconductivity, causing the early failure of PLA implants. For obviating this problem, coating, rather than incorporation, of PLA with calcium phosphate is considered to be effective. In this study, PLA plates were coated with granular carbonate apatite (CAp), the inorganic component of bone, using the thermal fusion bonding method. The water contact angles of the CAp-coated PLA (CAp/PLA) plates and PLA were 0.7° ± 0.1° and 90.3° ± 3.9°, respectively. Thus, CAp coating significantly improved the wettability of the PLA surface. Furthermore, the roughness (Ra) of CAp/PLA and PLA was 11.7 ± 2.2 μm and 1.8 ± 0.2 μm, respectively. CAp coating involved two types of micropores (~30–80 μm and ~2 μm). Thus, CAp coating provided a rough surface and micropores to the PLA plate. The CAp/PLA and uncoated PLA plates were fixed onto a rabbit tibial surface to evaluate their bone formation and adhesion abilities. Four weeks after implantation, new bone formed on the surface of the CAp/PLA plates. In contrast, no tissue was present in most of the regions between the uncoated PLA plate and the tibia. The tensile bond strengths of the CAp/PLA and PLA plates to the tibia were 4.0 ± 2.5 and 0 N, respectively. Thus, CAp coating of PLA promoted new bone formation on the plate surface and increased the ability to bond to the bone surface at an early stage. CAp coating of PLA is an effective strategy for achieving rapid and robust bone fixation.