Line narrowing of amide proton resonances in 2D NMR spectra of proteins
Line narrowing of amide proton resonances in 2D NMR spectra of proteins
复制标题
蛋白质二维 NMR 谱中酰胺质子共振谱线的窄化
DOI：
10.1021/ja00183a082
复制
发表时间：
1989
影响因子：
15
通讯作者：
D. Torchia
中科院分区：
文献类型：
--
作者：
A. Bax;L. Kay;S. W. Sparks;D. Torchia
（14） (a)烷基自由基加成到单取代烯烃的速率取决于烯烃取代基的性质。例如，CH2=CHCOCH的加成速率通常是CHI=CHCO2CH3的两倍（参考文献14b）。重要的是，简单的a-氨基烷基自由基是富电子的（高能SOMO），因此应该更有效地添加到缺乏电子的烯烃中。这应该与a-氨基烷基自由基的化学反应形成对比，后者在分子内添加了简单的烯烃基团（参考文献14c）。(b)选b。化学。，在t。英文编，1983,764,763及其中的参考文献。(c)哈特，D. J。;Tasi， Y。m。j。点。化学。SOC。1982, 104, 1430。伯内特博士；崔，J。k;哈特，d.j.；蔡，Y。同上，1984,106,8201。（15）例如，需要解决9的直接光敏化和set光敏化相对缺乏立体选择性和适度立体选择性的问题。蛋白质二维核磁共振谱中酰胺质子共振谱线窄化
(14) (a) The rates of alkyl radical addition to mono-substituted alkenes depend on the nature of the alkene substituents. For example, the addition rates to CH2=CHCOCH, are normally double those to CHI=CHCO2CH3 (ref 14b). Importantly, simple a-amino alkyl radicals are electron rich (high-energy SOMO) and thus should add to electron poor olefins more efficiently. This should be contrasted to the chemistry of a-amido alkyl radicals which add intramolecularly to simple alkene groupings (ref 14c). (b) Giese, B. Angew. Chem., In t . Ed. Engl. 1983, 764, 763 and references therein. (c) Hart, D. J . ; Tasi, Y . M. J . Am. Chem. SOC. 1982, 104, 1430. Burnett, D. A.; Choi, J . K.; Hart, D. J.; Tsai, Y . M. Ibid. 1984, 106, 8201. (1 5 ) For example, the comparative lack of and modest stereoselectivity of the respective direct and SET-sensitized photocyclizations of 9 needs to be addressed. Line Narrowing of Amide Proton Resonances in 2D NMR Spectra of Proteins