Effects of ecologically relevant concentrations of cadmium in a freshwater fish.
Effects of ecologically relevant concentrations of cadmium in a freshwater fish.
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DOI：
10.1016/j.ecoenv.2016.03.046
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发表时间：
2016-08
影响因子：
6.8
通讯作者：
L. Pereira;J. Ribas;T. Vicari;S. B. Silva;J. Stival;A. Baldan;F. X. Valdez Domingos;M. Grassi;M. Cestari;H. C. Silva de Assis
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文献类型：
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作者：
L. Pereira;J. Ribas;T. Vicari;S. B. Silva;J. Stival;A. Baldan;F. X. Valdez Domingos;M. Grassi;M. Cestari;H. C. Silva de Assis
在鲶鱼 Rhamdia quelen 中评估了生态相关镉 (Cd) 浓度的亚慢性影响。将鱼暴露于镉（0、0.1、1、10 和 100 µg L−1）中 15 天。在暴露于 10 和 100 µg L−1 镉的鱼的肝脏中观察到生物富集。肝脏谷胱甘肽 S-转移酶活性在 0.1 和 1 µg L−1 时下降，在 100 µg L−1 时上升，并且所有测试浓度下的脂过氧化作用均增加。暴露于 0.1、1 和 100 µg L−1Cd 的鱼的肝脏病变指数有所增加。在肾脏中，所有暴露组的过氧化氢酶活性和 LPO 均降低。在Cd最高浓度下，谷胱甘肽过氧化物酶、乙氧唑啉-O-脱乙基酶活性和金属硫蛋白增加，但还原型谷胱甘肽水平下降。在 0.1 和 100 µg L−1 浓度下观察到遗传毒性。没有观察到神经毒性。结果表明，低浓度（μg L−1 范围）的 Cd 会导致该淡水鱼的肝、肾和血液学改变。
Sub-chronic effects of ecologically relevant concentrations of cadmium (Cd) were evaluated in the catfishRhamdia quelen. The fish were exposed to Cd (0, 0.1, 1, 10 and 100 μg L−1) for 15 days. Bioconcentration was observed in the liver of fish exposed to 10 and 100 μg L−1of cadmium. The liver glutathione S-transferase activity decreased at 0.1 and 1 μg L−1and increased at 100 μg L−1and lipoperoxidation increased in all tested concentrations. Fish exposed to 0.1, 1 and 100 µg L−1Cd presented increase in hepatic lesion index. In the kidney, the catalase activity and LPO reduced in all exposed groups. The gluthatione peroxidase, etoxiresorufin-O-deethylase activities and metallothionein increased at the highest concentration of Cd, but the level of reduced glutathione decreased. The genotoxicity was observed at 0.1 and 100 μg L−1. Neurotoxicity was not observed. The results showed that low concentrations (range of μg L−1) of Cd caused hepato-, nephro- and hematological alterations in this freshwater fish species.