Marijuana Use and Renal Function Among US Adults
Marijuana Use and Renal Function Among US Adults
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DOI：
10.1016/j.amjmed.2017.10.051
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发表时间：
2018-04-01
影响因子：
5.9
通讯作者：
Mittleman, Murray A.
中科院分区：
文献类型：
--
作者：
Lu, Chang;Papatheodorou, Stefania I.;Mittleman, Murray A.
背景：近年来，医用大麻合法化或零售大麻合法化的州越来越多，这可能会给普通人群的大麻使用模式带来潜在的变化。然而，急性和慢性大麻使用对包括肾功能在内的许多相关健康结果的健康影响在很大程度上仍未得到检验。在这项研究中，我们旨在评估最近和过去使用大麻与肾功能之间的关系。方法：我们对2007年至2014年全国健康与营养检查调查中的13995名18至59岁的美国成年人进行了横断面研究。我们使用加权多变量线性回归检查了大麻使用与血清肌酐浓度、估计肾小球滤过率（eGFR）以及2期或以上慢性肾脏疾病的几率之间的关系。结果：在研究人群中，6483人为从未使用过，5499人为过去使用过，2013人为当前使用过。大麻的使用与血清肌酐、eGFR或患2期或更严重慢性肾脏疾病的几率没有显著关联。血清肌酐和eGFR在过去和现在服用者和从未服用者之间有上升趋势，但没有达到统计学意义。在仅限于无心血管疾病人群的敏感性分析中，所有关联保持不变。结论：我们没有观察到当前或过去自我报告的大麻使用与肾功能测量之间有任何临床意义的关联。(C) 2018爱思唯尔公司版权所有。
BACKGROUND: In recent years, the number of states that have legalized medical marijuana or retail sales has increased, bringing potential changes of marijuana use pattern among the general population. However, health effects of acute and chronic marijuana use on many relevant health outcomes, including renal function, remain largely unexamined. In this study, we aimed to assess the association between recent and past marijuana use and renal function.METHODS: We conducted a cross-sectional study among 13,995 US adults aged 18 to 59 years in the National Health and Nutrition Examination Survey from 2007 to 2014. We examined associations between marijuana use and serum creatinine concentration, estimated glomerular filtration rate (eGFR), and odds of having stage 2 or greater chronic kidney disease using weighted multivariable linear regression.RESULTS: In the study population, 6483 were never users, 5499 were past users, and 2013 were current users. Marijuana use did not have a significant association with serum creatinine, eGFR, or odds of having stage 2 or greater chronic kidney disease. Serum creatinine and eGFR had an increasing trend comparing past and current users with never users that did not reach statistical significance. All associations remained unchanged in the sensitivity analysis restricted to people without cardiovascular disease.CONCLUSIONS: We did not observe any clinically significant association between current or past selfreported marijuana use and measures of kidney function. (C) 2018 Elsevier Inc. All rights reserved.