Metal Chelating Crosslinkers Form Nanogels with High Chelation Stability.
Metal Chelating Crosslinkers Form Nanogels with High Chelation Stability.
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DOI：
10.1039/c3tb21104e
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发表时间：
2013-12-14
期刊：
影响因子：
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通讯作者：
Almutairi A
中科院分区：
文献类型：
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作者：
Lux J;Chan M;Elst LV;Schopf E;Mahmoud E;Laurent S;Almutairi A
我们提出了一系列的水凝胶纳米粒子（纳米凝胶）纳入无环或环状金属螯合物作为交联剂。这些交联剂用于配制基于聚丙烯酰胺的纳米凝胶（直径50至85 nm），产生具有增强的弛豫率（比Dotarem®高多达6倍）的造影剂，因为这种纳米凝胶结构减缓了螯合剂的翻滚频率并允许快速的水交换。重要的是，这些纳米凝胶还在动力学上和动力学上稳定螯合剂内的Gd 3+，以防止通过transmethalo的金属置换，这将降低与游离Gd 3+释放相关的毒性。这种螯合稳定性表明螯合交联剂策略可能被证明对金属螯合纳米颗粒在医学中的其他应用有用，包括其他成像方式和放射疗法。
We present a series of hydrogel nanoparticles (nanogels) incorporating either acyclic or cyclic metal chelates as crosslinkers. These crosslinkers are used to formulate polyacrylamide-based nanogels (diameter 50 to 85 nm) yielding contrast agents with enhanced relaxivities (up to 6-fold greater than Dotarem®), because this nanogel structure slows the chelator's tumbling frequency and allows fast water exchange. Importantly, these nanogels also stabilize Gd3+ within the chelator thermodynamically and kinetically against metal displacement through transmetallation, which should reduce toxicity associated with release of free Gd3+. This chelation stability suggests that the chelate crosslinker strategy may prove useful for other applications of metal-chelating nanoparticles in medicine, including other imaging modalities and radiotherapy.