AUTORADIOGRAPHIC LOCALIZATION OF D1 AND D2 DOPAMINE-RECEPTORS IN THE HUMAN-BRAIN
AUTORADIOGRAPHIC LOCALIZATION OF D1 AND D2 DOPAMINE-RECEPTORS IN THE HUMAN-BRAIN
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DOI：
10.1016/0304-3940(88)90758-6
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发表时间：
1988-08-31
影响因子：
2.5
通讯作者：
VAUQUELIN, G
中科院分区：
文献类型：
--
作者：
DEKEYSER, J;CLAEYS, A;VAUQUELIN, G
用放射自显影技术研究了多巴胺D_1和D_2受体在人脑不同部位的分布。这两种类型的多巴胺受体密度最高的是尾状核、壳核和伏核。虽然苍白球两段的D2受体密度相似，但苍白球内侧部的D1受体浓度是外侧部的三倍。D1和D2受体存在于杏仁核和黑质。这两种受体类型在小脑中都不存在。丘脑含有密度较低的D1受体，但没有D2受体。只有D2受体出现在脑下垂体腺的前叶。整个大脑皮层富含D1受体，而D2受体在低浓度时仅局限于内嗅区和扣带回皮质。
The distribution of dopamine D1and D2receptors in several human brain regions was investigated using autoradiography with the radioligands [3H]SCH 23390 and [3H]spiroperidol. The highest densities of both dopamine receptor types are seen in the nucleus caudatus, putamen and nucleus accumbens. Whereas the density of the D2receptors is similar in the two segments of the globus pallidus, the pars medialis of the globus pallidus contains a three-fold higher concentration of D1receptors than the pars lateralis. D1and D2receptors are present in the amygdala and substantia nigra. Both receptor types are absent in the cerebellum. The thalamus contains low densities of D1receptors but no D2receptors. Only D2receptors are seen in the anterior lobe of the pituitary gland. The whole cerebral cortex is rich in D1receptors, while D2receptors, in low concentrations, are confined to the entorhinal area and cingulate cortex.