Geographic distribution and clonal diversity of Streptococcus pneumoniae serotype 1 isolates
Geographic distribution and clonal diversity of Streptococcus pneumoniae serotype 1 isolates
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DOI：
10.1128/jcm.41.11.4966-4970.2003
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发表时间：
2003-11-01
影响因子：
9.4
通讯作者：
Spratt, BG
中科院分区：
文献类型：
--
作者：
Brueggemann, AB;Spratt, BG
血清1型肺炎球菌是导致严重疾病的主要原因，与疾病暴发有关，但很少携带。七价结合疫苗的高发病率和缺乏该血清型的覆盖率促使从最近的侵袭性疾病病例中收集了166个地理上不同的血清型分离物。通过多位点序列分型，分离得到16个克隆，这些克隆可分为3个主要谱系，但地理分布差异很大。A株主要来自欧洲和北美，B株主要来自非洲和以色列，C株主要来自智利。一个国家内个体克隆的存在与血清1型疾病的流行之间没有明确的关联。
Serotype 1 pneumococci are a major cause of serious disease and have been associated with outbreaks but are rarely carried. The high attack rate and lack of coverage of this serotype by the heptavalent conjugate vaccine prompted the characterization of a geographically diverse collection of 166 serotype 1 isolates from recent cases of invasive disease. The isolates were resolved by multilocus sequence typing into 16 clones, which clustered into three major lineages with very different geographic distributions. Lineage A isolates were exclusively from Europe and North America, lineage B isolates were predominantly from Africa and Israel, and lineage C isolates were mainly from Chile. There was no clear association between the presence of individual clones within a country and the prevalence of serotype 1 disease.