Axial rigidity and quality of life in patients with Parkinson's disease: a preliminary study
Axial rigidity and quality of life in patients with Parkinson's disease: a preliminary study
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DOI：
10.1007/s11136-010-9818-y
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发表时间：
2011-08-01
影响因子：
3.5
通讯作者：
Munoz-Hellin, Elena
中科院分区：
文献类型：
--
作者：
Cano-de-la-Cuerda, Roberto;Vela-Desojo, Lydia;Munoz-Hellin, Elena
僵硬是帕金森病（PD）的主要症状，通常通过被动屈曲和伸展患者的肢体来评估。采用客观测量方法检查PD患者的僵硬程度，包括腕、肘、膝和躯干。本研究旨在探讨轻至中度PD患者躯干刚性的客观测量与健康相关生活质量（HRQoL）和功能状态之间的关系。采用等速测力仪Biodex System 3对36例PD患者的躯干僵硬度进行评估。HRQoL采用EuroQol-5D和帕金森病问卷-39项（PDQ-39）进行评估。功能状态用Schwab和England量表测定。躯干僵硬度与HRQoL有相关性，HRQoL由行动力、认知和柱头PDQ-39域和总PDQ-39分评估。用等速测力仪和EuroQoL-5D评估躯干肌张力之间没有相关性。功能状态与躯干伸肌在所有角速度下的刚度相关。本研究结果提示轴向运动障碍影响PD患者的生活质量和功能状态。需要进一步研究轴向刚性定量评估装置，以确定疾病严重程度较高的PD患者躯干刚性与HRQoL量表的关系。
Rigidity is a cardinal symptom of Parkinson's disease (PD) and is often clinically assessed by passively flexing and extending a patient's limb. Objective measurements had been employed to examine rigidity in PD subjects, including wrist, elbow, knee and trunk. This study aimed to investigate the relationship between an objective measurement of trunk rigidity and health-related quality of life (HRQoL) and functional status in patients with mild to moderate PD.An isokinetic dynamometer Biodex System 3 was employed to assess trunk rigidity in 36 PD patients. HRQoL was assessed with the EuroQol-5D and Parkinson's Disease Questionnaire-39 items (PDQ-39). Functional status was measured with the Schwab and England scale.Trunk rigidity was correlated with the HRQoL assessed with the mobility, cognition and stigma PDQ-39 domains and the total PDQ-39 scores. No correlations were found among trunk muscle tone assessed with the isokinetic dynamometer and the EuroQoL-5D. Functional status was correlated with the trunk extensors rigidity at all angular velocities.The results from this study suggest that the axial motor impairments impact on QoL and functional status in patients with PD. Further studies are needed with quantitative devices for axial rigidity assessment to determine the relationship between trunk rigidity in PD patients with higher disease severity and HRQoL scales.