Expression of CD62L on Donor CD4+ T Cells in Allografts: Correlation with Graft-Versus-Host Disease after Unmanipulated Allogeneic Blood and Marrow Transplantation
Expression of CD62L on Donor CD4+ T Cells in Allografts: Correlation with Graft-Versus-Host Disease after Unmanipulated Allogeneic Blood and Marrow Transplantation
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DOI：
10.1007/s10875-009-9293-9
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发表时间：
2009-09-01
影响因子：
9.1
通讯作者：
Huang, Xiao-Jun
中科院分区：
文献类型：
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作者：
Chang, Ying-Jun;Zhao, Xiang-Yu;Huang, Xiao-Jun
本研究的目的是探讨表达CD 62 L的供体CD 4（+）T细胞与移植结果的关系。我们报告了对31例接受Bu/Cy方案治疗的患者进行前瞻性分析，随后进行未经处理的血液和骨髓移植。输注的CD 4（+）CD 45 RO（+）CD 62 L（+）细胞分别为0.31（0.05-1.10）× 10（8）/kg、0.22（0.03-0.95）× 10（8）/kg和0.17（0.01-0.81）× 10（8）/kg。II至IV级aGVHD的发生率为36%。在多变量分析中，输注> 0.22 × 10（8）CD 4（+）CD 45 RA（+）CD 62 L（+）细胞/kg增加了II级至IV级aGVHD的风险（HR = 4.741，95%CI = 1.037-21.662，P = 0.045）。31例患者中有13例发生cGVHD，接受> 0.45 × 10（8）CD 4（+）CD 45 RA（+）细胞输注/kg的患者发生cGVHD的风险增加（HR = 4.614，95%CI = 1.265-16.829，我们的结果表明，高细胞剂量的CD 4（+）CD 45 RA（+）CD 62 L（+）细胞增加了II-IV级aGVHD的发生率。在我们的移植环境中，大量的CD 4（+）CD 45 RA（+）细胞输注与cGVHD风险增加相关。
The aim of this study was to investigate the association of donor CD4(+) T cells expressing CD62L with transplant outcomes.We report a prospective analysis of 31 patients who were treated with a Bu/Cy regimen, followed by unmanipulated blood and marrow transplantation.Median number (range) of CD4(+)CD62L(+), CD4(+)CD45RA(+)CD62L(+), and CD4(+)CD45RO(+)CD62L(+) cells infused were 0.31(0.05-1.10)x10(8)/kg, 0.22(0.03-0.95)x 10(8)/kg, and 0.17(0.01-0.81)x10(8)/kg, respectively. The incidence of grades II to IV aGVHD was 36%. In a multivariate analysis, infusion of > 0.22 x 10(8) CD4(+)CD45RA(+)CD62L(+) cells infused/kg increased the risk of grades II to IV aGVHD (HR = 4.741, 95% CI = 1.037-21.662, P = 0.045). Thirteen of 31 patients experienced cGVHD, the risk of cGVHD was increased in patients receiving > 0.45 x 10(8) CD4(+)CD45RA(+) cells infused/kg (HR = 4.614, 95% CI = 1.265-16.829, P = 0.021).Our results suggest that a high cell dose of CD4(+)CD45RA(+)CD62L(+) cells increase the incidence of grades II-IV aGVHD. A high number of CD4(+)CD45RA(+) cells infused were associated with increased risk of cGVHD in our transplant settings.