Liver Biopsy in Children: Position Paper of the ESPGHAN Hepatology Committee
Liver Biopsy in Children: Position Paper of the ESPGHAN Hepatology Committee
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DOI：
10.1097/mpg.0000000000000632
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发表时间：
2015-03-01
影响因子：
2.9
通讯作者：
Knisely, Alexander S.
中科院分区：
文献类型：
--
作者：
Dezsofi, Antal;Baumann, Ulrich;Knisely, Alexander S.
肝活检（LB）仍然是获得肝组织进行组织病理学检查的标准程序，也是许多实质性肝脏疾病诊断、预后和管理的有价值工具。这份立场文件的目的是总结目前的做法，儿科LB和提出建议，其性能。虽然肝脏组织学检查在评估预后和探索治疗方法方面很重要，但无创技术（如影像学、实验室标志物）可能取代肝脏组织学检查。LB的适应症随着目前对儿科肝病病因、病理机制和治疗选择的认识不断发展而不断变化。对成人和儿科文献进行了综述，以评估LB的现有临床实践，重点关注儿科的技术、适应症、并发症风险和禁忌症。本立场文件介绍了LB的类型，适应症，并发症，禁忌症，和儿科LB的基本检查表。
Liver biopsy (LB) is still the criterion standard procedure for obtaining liver tissue for histopathological examination and a valuable tool in the diagnosis, prognosis, and management of many parenchymal liver diseases. The aim of this position paper is to summarise the present practice of paediatric LB and make recommendations about its performance. Although histological evaluation of the liver is important in assessing prognosis and exploring treatment, noninvasive techniques (ie, imaging, laboratory markers) may replace use of liver histology. The indications for LB are changing as present knowledge of aetiologies, pathomechanism, and therapeutic options in paediatric liver disease is evolving. Adult and paediatric literature was reviewed to assess the existing clinical practice of LB with focus on the technique, indications, risk of complications, and contraindications in paediatrics. This position paper presents types of LB, indications, complications, contraindications, and an essential checklist for paediatric LB.