Changing clinical presentation and survival in HIV-associated tuberculosis after highly active antiretroviral therapy
Changing clinical presentation and survival in HIV-associated tuberculosis after highly active antiretroviral therapy
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DOI：
10.1097/00126334-200104010-00006
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发表时间：
2001-04-01
期刊：
影响因子：
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通讯作者：
Ippolito, G
中科院分区：
文献类型：
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作者：
Girardi, E;Palmieri, F;Ippolito, G
Objective: To assess changes in clinical presentation and outcome of HIV-associated tuberculosis (TB) before and after widespread implementation of highly active antiretroviral therapy (HAART).Methods: We reviewed clinical charts of HIV-infected patients with culture confirmed pulmonary TB in two referral clinical centers in Rome, Italy. The 67 patients diagnosed in 1995 to 1996 were compared with 51 patients diagnosed in 1997 to 1998. To analyze factors associated with survival we used a Cox model including antiretroviral therapy as a time-dependent covariate.Results: Patients diagnosed in 1997 to 1998 were more likely to have TB as the first AIDS-defining illness (78% versus 58%, p < .05), to have HIV diagnosed
