CHANGES IN LYMPHOCYTE BETA-ADRENERGIC RECEPTORS IN DEPRESSION AND MANIA
CHANGES IN LYMPHOCYTE BETA-ADRENERGIC RECEPTORS IN DEPRESSION AND MANIA
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DOI：
10.1016/0165-1781(79)90061-1
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发表时间：
1979-01-01
影响因子：
11.3
通讯作者：
GOODWIN, FK
中科院分区：
文献类型：
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作者：
EXTEIN, I;TALLMAN, J;GOODWIN, FK
在从患有严重情感障碍的患者和对照中获得的淋巴细胞中体外研究了β-肾上腺素能受体。与对照组和情绪正常的患者相比，抑郁症和躁狂患者的 L-[3H]-二氢阿普洛尔特异性结合均减少。在躁狂症和抑郁症患者中，异丙肾上腺素刺激的环 AMP 生成减少，但前列腺素 E1 刺激的情况则不然。显然，淋巴细胞β-受体功能在抑郁症和躁狂症中下降。这种减少可能是躁狂症和抑郁症中大脑β-受体变化的指标，或者可能简单地反映了外周β-受体响应应激引起的循环儿茶酚胺增加的稳态调节。
The .beta.-adrenergic receptors were studied in vitro in lymphocytes obtained from patients with major affective disorders and from controls. Specific L-[3H]-dihydroalprenolol binding was decreased in both depressed and manic patients compared to controls and euthymic patients. Isoproterenol-stimulated, but not prostaglandin E1-stimulated, cyclic AMP production was decreased in manic and depressed patients. Apparently, lymphocyte .beta.-receptor functioning decreased in depression and mania. This decrease may be an index of changes in brain .beta.-receptors in mania and depression, or may simply reflect homeostatic regulation of peripheral .beta.-receptors in response to stress-induced increases in circulating catecholamines.