MAGNETIC-RESONANCE-IMAGING MORPHOMETRIC ANALYSIS OF CEREBRAL VOLUME LOSS IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
MAGNETIC-RESONANCE-IMAGING MORPHOMETRIC ANALYSIS OF CEREBRAL VOLUME LOSS IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
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DOI：
10.1001/archneur.1993.00540030016007
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发表时间：
1993-03-01
影响因子：
--
通讯作者：
GRANT, I
中科院分区：
文献类型：
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作者：
JERNIGAN, TL;ARCHIBALD, S;GRANT, I
磁共振成像用于比较有和没有医学症状的人类免疫缺陷病毒1型抗体阳性的男性受试者和两组血清阴性的男性受试者(HIV阴性)。控制对象包括感染HIV-1的高危男性和低风险男性。HIV阳性受试者中没有一人符合HIV相关痴呆症的标准，也没有一人患有可检测到的机会性脑病。定量图像分析技术被用来估计脑室和皮质脑脊液、大脑白质以及皮质和皮质下灰质结构的体积。与低危对照组受试者和无症状的HIV阳性受试者相比，非痴呆但有医学症状的HIV阳性受试者脑脊液显著增加，大脑白质体积减少，大脑灰质体积减少。然而，出乎意料的是，在血清阴性的高危对照受试者中，也出现了一些脑脊液增加和灰质体积减少的情况。
Magnetic resonance imaging was used to compare male subjects seropositive for antibody to human immunodeficiency virus type 1 (HIV positive), with and without medical symptoms, with two groups of men who were seronegative (HIV negative). The control subjects included men at high risk for exposure to HIV-1 and those at low risk. None of the HIV-positive subjects met criteria for HIV-associated dementia or had detectable opportunistic brain disease. Quantitative image-analytic techniques were used to estimate volumes of ventricular and cortical cerebrospinal fluid, cerebral white matter, and cortical and subcortical gray matter structures. Relative to low-risk group control subjects and asymptomatic HIV-positive subjects, nondemented but medically symptomatic HIV-positive subjects showed significant increases in cerebrospinal fluid, reduced volume of cerebral white matter, and reduced cerebral gray matter volumes. Unexpectedly, however, some cerebrospinal fluid increases and gray matter volume decreases were present in the seronegative high-risk control subjects as well.