Antimicrobial resistance in pig faecal samples from The Netherlands (five abattoirs) and Sweden
Antimicrobial resistance in pig faecal samples from The Netherlands (five abattoirs) and Sweden
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DOI：
10.1093/jac/45.5.663
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发表时间：
2000-05-01
影响因子：
5.2
通讯作者：
Stobberingh, EE
中科院分区：
文献类型：
--
作者：
van den Bogaard, AEJM;London, N;Stobberingh, EE
粪便指示细菌，大肠杆菌和肠球菌的抗生素耐药性的流行和程度，确定在1321个粪便样本收集的猪在荷兰的5个屠宰场和100个样本从瑞典猪。在荷兰样本中，观察到E.猪用抗生素阿莫西林、土霉素和甲氧苄啶的检出率分别为70-94%、78-98%和62-96%。此外，氯霉素（55-67%）和新霉素（38-67%）的流行率相对较高。对于测试的其他化合物，患病率低于10%。高抗E.大肠杆菌在所有荷兰屠宰场表现出相同的趋势，虽然屠宰场之间的显着差异进行了观察。瑞典的高抗E.除呋喃妥因、庆大霉素、氟甲喹和环丙沙星外，其他抗生素对大肠杆菌的感染率均显著降低。所有肠球菌均对阿莫西林敏感，在4-6%的荷兰样本中观察到对庆大霉素的高水平耐药性。红霉素和土霉素耐药率高，耐药程度高。达福普汀-奎奴普汀耐药率为6%-8%，万古霉素耐药率为24%-46%。除阿莫西林外，所有测试化合物在屠宰场之间均存在显著差异。在瑞典人群中，除阿莫西林和庆大霉素外，肠球菌的患病率和耐药程度均显着降低。本点流行率研究表明，指示菌E。大肠杆菌和肠球菌在两个国家的猪粪便样本中存在差异，反映了猪抗生素使用的差异。为了分析在屠宰场之间观察到的差异，需要关于原产地农场和抗生素消耗的额外信息。
The prevalence and degree of antibiotic resistance of faecal indicator bacteria, Escherichia coli and enteroccoci, were determined in 1321 faecal samples collected from pigs at five abattoirs in The Netherlands and in 100 samples from Swedish pigs. In the Dutch samples a high prevalence of resistance was observed in E. coli for three commonly used antibiotics in pig medicine, amoxycillin (70-94%), oxytetracycline (78-98%) and trimethoprim (62-96%). Also, the prevalence for chloramphenicol (55-67%) and neomycin (38-67%) was relatively high. For the other compounds tested the prevalence was less than 10%. The percentage of samples with a high degree of resistant E. coli showed the same tendency in all Dutch abattoirs although significant differences between the abattoirs were observed. The percentage of Swedish samples with a high degree of resistant E. coli was significantly lower for all antibiotics except nitrofurantoin, gentamicin, flumequin and ciprofloxacin. All enterococci were susceptible to amoxycillin and high-level resistance to gentamicin was observed in 4-6% of the Dutch samples. A high prevalence of resistance and a high degree of resistance was found for erythromycin and oxytetracycline. The prevalence of resistance to dalfopristin-quinupristin ranged from 6 to 8% and for vancomycin from 24 to 46%. Significant differences between the abattoirs were found for all compounds tested except amoxycillin. In the Swedish population both the prevalence and degree of resistance in enterococci were significantly lower except for amoxycillin and gentamicin. This point prevalence study showed that the prevalence and degree of antibiotic resistance in indicator bacteria, E. coli and enterococci, in faecal samples from pigs differed between two countries and reflected differences in antibiotic usage in pigs. To analyse the differences observed between the slaughterhouses, additional information about the farms of origin and antibiotic consumption is necessary.