Zinc Treatment for 5 or 10 Days Is Equally Efficacious in Preventing Diarrhea in the Subsequent 3 Months among Bangladeshi Children
Zinc Treatment for 5 or 10 Days Is Equally Efficacious in Preventing Diarrhea in the Subsequent 3 Months among Bangladeshi Children
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DOI：
10.3945/jn.110.120857
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发表时间：
2011-02-01
影响因子：
4.2
通讯作者：
Black, Robert E.
中科院分区：
文献类型：
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作者：
Alam, Dewan S.;Yunus, Mohammad;Black, Robert E.
我们在孟加拉国农村进行了一项随机、双盲、安慰剂对照的社区试验，在4-59个月的儿童中比较了5天和10天锌治疗对急性儿童腹泻（ACD）初始治疗后90天随访期间腹泻发生率和持续时间的疗效。患有ACD的儿童（n = 1622）被随机分配到5或10天的锌治疗组。女性现场工作人员每天访问每个孩子，监督锌的管理，记录当前事件的持续时间，以及随后3个月腹泻的发生和持续时间。在90天随访期间，5天组（1.08 +/- 1.38次发作）和10天组（1.02 +/- 1.35次发作）的腹泻发生率无差异（P = 0.35）。两组儿童的腹泻发作持续时间相当（分别为3.1 +/- 5.6 d vs. 2.9 +/- 5.6 d，5 d vs. 10 d; P = 0.64），组间平均差异在定义的等效范围内。在90天的随访中，两组间首次发病的时间和发生腹泻的儿童比例也没有差异。这些研究结果表明，在孟加拉国儿童中，5天的ACD锌治疗在随后的3个月内预防腹泻方面与10天一样有效。J.营养141：312-315，2011.
We conducted a randomized, double-blind placebo controlled, community trial in rural Bangladesh in children 4-59 mo of age to compare the efficacy of a 5- and 10-d course of zinc therapy on the incidence and duration of diarrhea over the subsequent 90-d follow-up after initial treatment for an acute childhood diarrheal (ACD) episode. Children (n = 1622) with ACD were randomly allocated to either 5 or 10 d of zinc treatment. Female field workers visited each child daily, supervised the administration of zinc, recorded the duration of current episode, and the occurrence and duration of diarrhea over the subsequent 3 mo. The incidence of diarrhea over the 90 d of follow-up did not differ between the 5-d (1.08 +/- 1.38 episodes) and 10-d (1.02 +/- 1.35 episodes) groups (P = 0.35). Children in both groups experienced a comparable duration of diarrheal episodes (3.1 +/- 5.6 d vs. 2.9 +/- 5.6 d, 5-d vs. 10-d, respectively; P = 0.64) with a mean difference between groups within the defined range of equivalence. Time to onset of the first episode and the proportion children experiencing diarrhea during the 90-d follow-up also did not differ between groups. These findings suggest that among Bangladeshi children, a 5-d zinc treatment for ACD is as efficacious as 10 d in preventing diarrhea in the subsequent 3 mo. J. Nutr. 141: 312-315, 2011.