Inhibitory influence of monoamines and brainstem monoaminergic regions on the medullary swallowing reflex
Inhibitory influence of monoamines and brainstem monoaminergic regions on the medullary swallowing reflex
复制标题
单胺和脑干单胺能区对延髓吞咽反射的抑制作用
DOI：
10.1016/0304-3940(86)90117-5
复制
发表时间：
1986
影响因子：
2.5
通讯作者：
A. Jean
中科院分区：
文献类型：
--
作者：
J. Kessler;A. Jean
吞咽是一种多突触反射，主要由位于孤束核（NTS）外侧区的神经元网络组织。单胺微量注射（5-羟色胺，去甲肾上腺素; 1纳摩尔，50纳升）的NTS的吞咽区域内产生了显着减少吞咽的次数引起的重复刺激的上级喉神经。刺激，与同心双极电极，重叠的单胺能区域，如中缝大核，中缝苍白核，内侧丘系，腹外侧网状结构，蓝斑和连合核脑干结构，引起抑制喉发起的吞咽。这些结果表明，在NTS内，吞咽反射的单胺能抑制可能起源于单胺能脑干区域。
Swallowing is a polysynaptic reflex organized by a neuronal network localized mainly within the lateral region of the nucleus tractus solitarius (NTS). Monoamine microinjections (serotonin, noradrenaline; 1 nmol, 50 nl) within the swallowing region of the NTS produced a significant decrease in the number of swallows elicited by repetitive stimulation of the superior laryngeal nerve. Stimulation, with concentric bipolar electrodes, of several brainstem structures overlapping monoaminergic regions such as the nucleus raphe magnus, the nucleus raphe pallidus, the lemniscus medialis, the ventrolateral reticular formation, the locus coeruleus and the nucleus commissuralis, induced an inhibition of the laryngeal-initiated swallowing. These results indicate the existence, within the NTS, of a monoaminergic inhibition of the swallowing reflex which might originate from monoaminergic brainstem regions.