Protracted anaphylaxis developed after peginterferon α-2a administration for chronic hepatitis C
Protracted anaphylaxis developed after peginterferon α-2a administration for chronic hepatitis C
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DOI：
10.3748/wjg.v21.i9.2826
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发表时间：
2015-03-07
影响因子：
4.3
通讯作者：
Kinoshita, Kazuo
中科院分区：
文献类型：
--
作者：
Sakatani, Akihiko;Doi, Yoshinori;Kinoshita, Kazuo
聚乙二醇干扰素是一种用于治疗慢性病毒性肝炎的关键药物，众所周知，慢性病毒性肝炎会引起各种副作用。给药后立即发生的副作用包括头痛、恶心和流感样症状，如发热和关节痛。然而，过敏性休克的报告极为罕见。在此我们报告一位因慢性丙型肝炎而接受聚乙二醇干扰素α-2a治疗后出现休克症状的过敏反应患者。虽然患者在休克治疗后暂时好转，但过敏反应症状复发。由于聚乙二醇干扰素通常是在门诊基础上管理，重要的是要认识到危及生命的副作用，可能会在长期的方式发展。
Peginterferon is a key drug used to treat chronic viral hepatitis that is known for causing various side effects. Side effects occurring immediately after administration include headache, nausea, and influenza-like symptoms, such as fever and joint pain. However, reports of anaphylactic shock are extremely rare. Here we report a patient with protracted anaphylaxis who suffered shock symptoms after peginterferon alpha-2a administration for chronic hepatitis C. Although the patient improved temporarily with shock treatment, symptoms of anaphylaxis recurred. As peginterferon is often administered on an outpatient basis, it is important to recognize life-threatening side effects that may develop in a protracted manner.