AMPHETAMINE EFFECTS ON LONG-TERM POTENTIATION IN DENTATE GRANULE CELLS
AMPHETAMINE EFFECTS ON LONG-TERM POTENTIATION IN DENTATE GRANULE CELLS
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DOI：
10.1016/0091-3057(83)90263-0
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
GOLD, PE
中科院分区：
文献类型：
--
作者：
DELANOY, RL;TUCCI, DL;GOLD, PE
长时程增强（LTP）作为一种记忆的神经生理学类似物受到了广泛的关注。安非他明和其他几种儿茶酚胺激动剂可以增强各种训练情况下的行为评估记忆存储。本文观察了苯丙胺对高频刺激大鼠穿支所产生的长时程增强的影响。安非他明显然增强了LTP的发展下，一些，但不是所有的测试程序。研究中枢和外周的儿茶酚胺调节记忆储存的神经生物学基础，可能会增加检查儿茶酚胺对大脑功能的长期变化的一种特殊形式的影响。操纵LTP的能力可能被证明是检查这种现象的神经生物学相关性的重要辅助手段。
Long term potentiation (LTP) has received considerable attention as a neurophysiological analog of memory. Amphetamine and several other catecholamine agonists can enhance behaviorally-assessed memory storage in a variety of training situations. The effects of amphetamine on LTP produced by high frequency stimulation of the perforant path in rats was studied. Amphetamine apparently enhanced the development of LTP under some, but not all, testing procedures. Studies of the neurobiological bases by which central and peripheral catecholamines modulate memory storage may be augmented by examinations of catecholamine effects on a specific form of long-lasting change in brain function. The ability to manipulate LTP may prove to be an important aid in examinations of neurobiological correlates of this phenomenon.