Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: Relationship with endosomal lipid trafficking genes
Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: Relationship with endosomal lipid trafficking genes
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DOI：
10.1016/j.jpsychires.2012.10.019
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发表时间：
2013-02-01
影响因子：
4.8
通讯作者：
Turecki, Gustavo
中科院分区：
文献类型：
--
作者：
Freemantle, Erika;Mechawar, Naguib;Turecki, Gustavo
突触体膜中的胆固醇 (CHL) 和磷脂 (PL) 水平尤其会对细胞信号传导产生影响。自杀行为中外周 CHL 测量值的变化一直被报道。由于大脑中的 CHL 和 PL 周转对于突触维持和功能很重要，因此本研究的目的是确定自杀完成者和对照组之间的突触体胆固醇和磷脂水平是否存在差异。参与脂质运输的基因的表达测量表明，溶酶体酸性脂肪酶 A、胆固醇酯水解酶 (LIPA) 和大脑 PL 水平之间存在关联，暴力自杀时 LIPA 显着增加，并与大脑 PL 的改变相关。这项研究的结果表明，前额皮质中暴力自杀时 LIPA 表达介导的 PL 含量发生改变，这将对抑制性神经传递产生重要影响。 Crown 版权所有 (c) 2012 由 Elsevier Ltd 出版。保留所有权利。
Cholesterol (CHL) and phospholipid (PL) levels in synaptosomal membranes in particular can have an impact on cell signalling. Alterations in peripheral CHL measures have been consistently reported in suicidal behaviour. As CHL and PL turnover in the brain are important in synapse maintenance and function, the objective of this study was to determine if differences exist in synaptosomal cholesterol and phospholipid levels between suicide completers and controls. Expression measures of genes involved in lipid trafficking suggest an association between Lysosomal acid lipase A, cholesteryl ester hydrolase (LIPA) and brain PL levels, with LIPA being significantly increased in violent suicides and associated with alterations in brain PL The results of this study suggest an altered PL content mediated by LIPA expression in violent suicides in the prefrontal cortex, which would have important consequences for inhibitory neurotransmission. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.