Role of hydrogen sulfide in the pathology of inflammation.
Role of hydrogen sulfide in the pathology of inflammation.
复制标题
硫化氢在炎症病理学中的作用。
作者：
Bhatia M
硫化氢（H2S）是一种众所周知的有毒气体，其在人体中通过至少两种不同的酶的作用由氨基酸胱硫醚、同型半胱氨酸和半胱氨酸合成：胱硫醚-γ-裂解酶和胱硫醚-β-合成酶。在过去的几年里，H2S已经成为一种新的和越来越重要的生物介质。H2S的不平衡也已被证明与各种疾病状况有关。然而，定义H2S的确切病理生理学被证明是一个复杂的挑战。我们实验室最近的研究表明，H2S是一种新型的炎症介质，目前全球几个小组的工作重点是确定H2S在炎症中的作用。H2S与不同的炎症性疾病有关，如急性胰腺炎、败血症、关节炎和慢性阻塞性肺病（COPD）。对H2S在炎症中的作用的积极研究将揭示其在炎症条件下作用的病理生理学，并可能有助于为几种尚未治愈的疾病开发新的治疗方法。
Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-γ-lyase and cystathionine-β-synthase. In the past few years, H2S has emerged as a novel and increasingly important biological mediator. Imbalances in H2S have also been shown to be associated with various disease conditions. However, defining the precise pathophysiology of H2S is proving to be a complex challenge. Recent research in our laboratory has shown H2S as a novel mediator of inflammation and work in several groups worldwide is currently focused on determining the role of H2S in inflammation. H2S has been implicated in different inflammatory conditions, such as acute pancreatitis, sepsis, joint inflammation, and chronic obstructive pulmonary disease (COPD). Active research on the role of H2S in inflammation will unravel the pathophysiology of its actions in inflammatory conditions and may help develop novel therapeutic approaches for several, as yet incurable, disease conditions.