Blastocystis subtypes and their association with Irritable Bowel Syndrome
Blastocystis subtypes and their association with Irritable Bowel Syndrome
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DOI：
10.1016/j.mehy.2018.04.006
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发表时间：
2018-07-01
影响因子：
4.7
通讯作者：
Trelis, Maria
中科院分区：
文献类型：
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作者：
Cifre, Susana;Gozalbo, Monica;Trelis, Maria
芽囊原虫属是一种常见的肠道原生动物，影响人类和动物。这种寄生虫作为病原体的作用仍然存在争议，它被怀疑与肠易激综合征（IBS）有关，IBS是一种功能性肠道疾病，其特征是与肠道习惯改变相关的慢性或复发性腹痛。在电子数据库、图书馆、期刊门户网站等中广泛检索寄生虫与IBS之间相关性的报告，无语言限制。评选不受日期限制，但优先考虑过去七年发表的文章。我们调查了关于囊胚和IBS共存的证据，以及寄生虫在发病机制和临床表现中的意义。只有标准化的寄生虫学工具，辅以流行病学分析，才能澄清寄生虫携带是否与IBS及其作为人类病原体的地位有关。尽管已证实亚型之间的致病性和毒力存在差异，但芽囊原虫只能被视为生态失调的指标。这种寄生性真核生物的准确诊断，特别是在基因型和表型水平，以及肠道微生物群落的完整分析，必须包括在IBS患者的方案中。
Blastocystis spp. is a common intestinal protozoan that affects humans and animals. The role of this parasite as a pathogen is still controversial and it is suspected to be linked to Irritable Bowel Syndrome (IBS), a functional bowel disorder characterized by chronic or recurrent abdominal pain associated with altered intestinal habits. A broad search in electronic databases, libraries, portals of journals, etc. for reports on the association between the parasite and IBS without language restriction was performed. The selection was not restricted by date, but articles published in the last seven years were given preference. We investigated the evidence regarding Blastocystis and IBS coexistence as well as the implications of the parasite in pathogenesis and clinical manifestations. Only standardized parasitological tools, supplemented by epidemiological analysis, will be able to clarify whether parasite carriage could be connected to IBS and its status as a human pathogen. Although a variation in pathogenicity and virulence between subtypes has been confirmed, Blastocystis can only be considered an indicator of dysbiosis. Accurate diagnoses of this parasitic eukaryote, specifically at genotypic and phenotypic levels, as well as the complete analysis of the intestinal microbial communities, have to be included in the protocol of those patients with IBS.