GSK3β and the control of infectious bacterial diseases.
GSK3β and the control of infectious bacterial diseases.
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DOI：
10.1016/j.tim.2014.01.009
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发表时间：
2014-04
影响因子：
15.9
通讯作者：
Scott, David A.
中科院分区：
文献类型：
--
作者：
Wang, Huizhi;Kumar, Akhilesh;Lamont, Richard J.;Scott, David A.
Glycogen synthesis kinase 3β (GSK3β) has been shown to be a critical mediator of the intensity and direction of the innate immune system responding to bacterial stimuli. This review will focus on: (i) the central role of GSK3β in the regulation of pathogen-induced inflammatory responses through the regulation of pro- and anti-inflammatory cytokine production. (ii) The extensive ongoing efforts to exploit GSK3β for its therapeutic potential in the control of infectious diseases. (iii) The increasing evidence that specific pathogens target GSK3β-related pathways for immune evasion. A better understanding of complex bacterial–GSK3β interactions is likely to lead to more effective anti-inflammatory interventions and novel targets to circumvent pathogen colonization and survival.
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