Comparison of glycosyltransferase families using the profile hidden Markov model
Comparison of glycosyltransferase families using the profile hidden Markov model
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DOI：
10.1016/j.bbrc.2003.09.031
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发表时间：
2003-10-17
影响因子：
3.1
通讯作者：
Narimatsu, H
中科院分区：
文献类型：
--
作者：
Kikuchi, N;Kwon, YD;Narimatsu, H
为了研究糖基转移酶家族及其基序之间的关系，我们使用隐马尔可夫模型方法将CAZy数据库中的47个糖基转移酶家族分为GTS-A、-B、-C和-D四个超家族。根据GTS-A与催化核苷酸糖合成的核苷酸酰基转移酶家族的分类和相似性，我们认为GTS-A的起源可能是由GTS-B合成的古寡糖，而GTS-A的起源可能是编码核苷酸糖合成的基因作为供体，并进化为催化不同碳水化合物合成的糖基转移酶。我们还认为，每个超家族在相应的亚细胞成分中的不同进化增加了真核碳水化合物结构的复杂性。(C) 2003 Elsevier Inc.版权所有。
In order to investigate the relationship between glycosyltransferase families and the motif for them, we classified 47 glycosyltransferase families in the CAZy database into four superfamilies, GTS-A, -B, -C, and -D, using a profile Hidden Markov Model method. On the basis of the classification and the similarity between GTS-A and nucleotidylyltransferase family catalyzing the synthesis of nucleotide-sugar, we proposed that ancient oligosaccharide might have been synthesized by the origin of GTS-B whereas the origin of GTS-A might be the gene encoding for synthesis of nucleotide-sugar as the donor and have evolved to glycosyltransferases to catalyze the synthesis of divergent carbohydrates. We also suggested that the divergent evolution of each superfamily in the corresponding subcellular component has increased the complexities of eukaryotic carbohydrate structure. (C) 2003 Elsevier Inc. All rights reserved.