Meal-generated oxidative stress in type 2 diabetic patients
Meal-generated oxidative stress in type 2 diabetic patients
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DOI：
10.2337/diacare.21.9.1529
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发表时间：
1998-09-01
期刊：
影响因子：
16.2
通讯作者：
Taboga, C
中科院分区：
文献类型：
--
作者：
Ceriello, A;Lizzio, S;Taboga, C
目的-据报道，糖尿病患者体内自由基的产生增加，并参与糖尿病并发症的发病机制。在这项研究中，一个标准化的膳食管理10型2糖尿病患者和10名健康匹配的正常subjects，以评估其对血浆氧化应激generation.RESEARCH设计和方法的影响-在糖尿病患者，在基线和餐后，血浆丙二醛（MDA），维生素C，蛋白质SH组，尿酸，维生素E，和总血浆自由基捕获参数，其评价血浆中存在的已知和未知的抗氧化剂以及它们的相互协作引起的血浆抗氧化能力。结果-餐后，血浆MDA和维生素C增加，而蛋白质SH组，尿酸，维生素E，和总血浆自由基捕获参数降低更显着的糖尿病受试者比对照组。结论-这一发现表明，在吸收阶段，糖尿病患者体内会产生自由基。由于血糖，但不是胰岛素，糖尿病受试者比对照组显着增加，高血糖症可能在糖尿病患者餐后氧化应激的产生中发挥重要作用。
OBJECTIVE - Free radical production has been reported to be increased in diabetic patients and to be involved in the pathogenesis of diabetic complications. In this study, a standardized meal was administered to 10 type 2 diabetic patients and 10 healthy matched normal subjects to evaluate its effects on plasma oxidative stress generation.RESEARCH DESIGN AND METHODS - In diabetic patients, at baseline and after the meal, plasma malondialdehyde (MDA), vitamin C, protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter, which evaluates plasma antioxidant capacity due to known and unknown antioxidants present in the plasma as well as their mutual cooperation, were measured.RESULTS - After the meal, plasma MDA and vitamin C increased, while protein SH groups, uric acid, vitamin E, and total plasma radical-trapping parameter decreased more significantly in the diabetic subjects than in control subjects.CONCLUSIONS - This finding shows that in the absorptive phase, free radicals are produced in diabetic patients. Since plasma glucose, but not insulin, rose significantly more in diabetic subjects than in control subjects, hyperglycemia may play an important role in the generation of postprandial oxidative stress in diabetic patients.