It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration.
It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration.
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DOI：
10.3389/fbioe.2017.00068
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发表时间：
2017
影响因子：
5.7
通讯作者：
Di Maggio N
中科院分区：
文献类型：
--
作者：
Grosso A;Burger MG;Lunger A;Schaefer DJ;Banfi A;Di Maggio N
骨再生是一个复杂的过程，需要不同细胞和信号之间高度协调的相互作用以形成新的矿化组织。血管作为结构模板，围绕其发生骨发育，并且还将骨稳态的关键要素汇集到成骨微环境中，包括矿物质、生长因子和成骨祖细胞。血管内皮生长因子（VEGF）是血管生长的主要调节因子，在骨骼发育和出生后骨修复过程中，它是有效偶联血管生成和骨生成所必需的。在这里，我们将审查目前的知识状态之间的血管生成和成骨的分子串扰。特别地，我们将关注VEGF在耦合这两个过程中的作用以及VEGF剂量如何控制结果，特别是解决：（1）VEGF对间充质祖细胞的成骨分化的直接影响;（2）内皮细胞调节骨祖细胞的血管分泌功能;（3）免疫细胞的作用，例如，骨髓细胞和破骨细胞前体，由VEGF募集到成骨微环境。最后，我们将讨论新兴的战略，根据目前的生物学理解，以确保快速血管化和有效的骨形成再生医学。
Bone regeneration is a complex process requiring highly orchestrated interactions between different cells and signals to form new mineralized tissue. Blood vessels serve as a structural template, around which bone development takes place, and also bring together the key elements for bone homeostasis into the osteogenic microenvironment, including minerals, growth factors and osteogenic progenitor cells. Vascular endothelial growth factor (VEGF) is the master regulator of vascular growth and it is required for effective coupling of angiogenesis and osteogenesis during both skeletal development and postnatal bone repair. Here, we will review the current state of knowledge on the molecular cross-talk between angiogenesis and osteogenesis. In particular, we will focus on the role of VEGF in coupling these two processes and how VEGF dose can control the outcome, addressing in particular: (1) the direct influence of VEGF on osteogenic differentiation of mesenchymal progenitors; (2) the angiocrine functions of endothelium to regulate osteoprogenitors; (3) the role of immune cells, e.g., myeloid cells and osteoclast precursors, recruited by VEGF to the osteogenic microenvironment. Finally, we will discuss emerging strategies, based on the current biological understanding, to ensure rapid vascularization and efficient bone formation in regenerative medicine.
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影响因子：
15.9
作者：
Hu, Kai;Olsen, Bjorn R.
通讯作者：
Olsen, Bjorn R.
DOI：
10.1369/0022155413516347
发表时间：
2014-02
期刊：
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
影响因子：
--
作者：
Berendsen AD;Olsen BR
通讯作者：
Olsen BR
影响因子：
4.6
作者：
Duan, Xuchen;Murata, Yurie;Berendsen, Agnes D.
通讯作者：
Berendsen, Agnes D.
影响因子：
64.8
作者：
Kusumbe AP;Ramasamy SK;Adams RH
通讯作者：
Adams RH
影响因子：
64.8
作者：
通讯作者：
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