Miniaturization of thiol-organosilica nanoparticles induced by an anionic surfactant
Miniaturization of thiol-organosilica nanoparticles induced by an anionic surfactant
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DOI：
10.1016/j.jcis.2018.04.090
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发表时间：
2018-09-15
影响因子：
9.9
通讯作者：
Nakamura, Michihiro
中科院分区：
文献类型：
--
作者：
Doura, Tomohiro;Tamanoi, Fuyuhiko;Nakamura, Michihiro
硫醇基有机硅纳米粒子是一种具有生物医学应用前景的纳米材料。增强的渗透性和保留（EPR）效应可用于纳米材料生物医学应用中的肿瘤靶向，尺寸小于200 nm的纳米材料表现出最大的EPR效应。然而，直径小于200 nm的硫醇-有机二氧化硅纳米颗粒的合成对于使用本发明的常规合成方法的产率而言是无效的。在此，我们报告了一种有效的合成方法的硫醇有机硅纳米粒子的直径小于200 nm，使用阴离子表面活性剂的发展，并讨论其机制。与常规合成方法相比，使用十二烷基硫酸钠（SDS）加成合成方法或十二烷基苯磺酸钠（SDBS）加成合成方法实现了硫醇-有机硅纳米颗粒的大于10倍的小型化和小硫醇-有机硅纳米颗粒的生产效率的约40倍的增加。这是第一次报道了由阴离子表面活性剂诱导的有机硅纳米粒子的微型化。SDS加成法或SDBS加成法将加速硫醇基有机硅纳米粒子的生物医学应用。(C)2018爱思唯尔公司All rights reserved.
Thiol-organosilica nanoparticles are a promising nanomaterial for biomedical applications. The enhanced permeability and retention (EPR) effect is useful for tumor targeting within the biomedical applications of nanomaterials, and nanomaterials with a size of less than 200 nm exhibit the maximum EPR effect. However, the synthesis of thiol-organosilica nanoparticles with a diameter of less than 200 nm is not efficient for the yield using the present conventional synthetic methods. Herein, we report the development of an efficient synthetic method of thiol-organosilica nanoparticles with a diameter of less than 200 nm using an anionic surfactant and discuss its mechanism. Compared with the conventional synthetic methods, a greater than 10-fold miniaturization of thiol-organosilica nanoparticles and an approximately 40-fold increase in the production efficiency of small thiol-organosilica nanoparticles were achieved using the sodium dodecyl sulfate (SDS)-addition synthetic method or sodium dodecylbenzenesulfonate (SDBS)-addition synthetic method. This is the first report about the miniaturization of organosilica nanoparticles induced by an anionic surfactant. The SDS-addition synthetic method or SDBS-addition synthetic method will accelerate the biomedical applications of thiol-organosilica nanoparticles. (C) 2018 Elsevier Inc. All rights reserved.