Temperature-responsive magnetite/PEO-PPO-PEO block copolymer nanoparticles for controlled drug targeting delivery
Temperature-responsive magnetite/PEO-PPO-PEO block copolymer nanoparticles for controlled drug targeting delivery
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DOI：
10.1021/la702049d
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发表时间：
2007-12-04
期刊：
影响因子：
3.9
通讯作者：
Liu, Hui-Zhou
中科院分区：
文献类型：
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作者：
Chen, Shu;Li, Ying;Liu, Hui-Zhou
在这项研究中，由氧化铁纳米粒子和聚(乙烯亚胺)改性聚(环氧乙烷)-聚(环氧丙烷)-聚(环氧乙烷)(PEO-PPO-PEO)嵌段共聚物开发了温度响应型磁铁矿/聚合物纳米粒子。通过 TEM、XRD、DLS、VSM、FTIR 和 TGA 对颗粒进行了表征。典型产品具有类似于20 nm的磁铁矿核心和类似于40 nm的流体动力学直径，尺寸分布窄，并且在室温下具有大饱和磁化强度（51.34 emu/g）的超顺磁性。纳米颗粒最吸引人的特征是它们的温度响应体积转变特性。 DLS 结果表明，在评估温度从 20 到 35 ℃ 时，它们的平均流体动力学直径从 45 nm 急剧减小到 25 nm。纳米粒子水溶液的 FTIR 光谱中 C-O 伸缩带的温度依赖性演化表明，固定化嵌段共聚物在磁铁矿固体表面上发生了热诱导的自组装，并伴随着热诱导自组装。 通过共聚物从完全伸展状态到高度卷曲状态的构象变化。因此，共聚物壳可以充当。用于客体物质运输的温控“门”。通过在不同温度下切换聚合物壳的瞬时打开和关闭，可以很好地控制疏水性和亲水性模型药物的摄取和释放。在模拟人体条件下实现了约 3 天的持续释放。在原代小鼠实验中，包载药物的磁性纳米颗粒表现出良好的生物相容性，可有效治疗脊髓损伤。这种智能磁性纳米粒子是广泛生物医学应用的有吸引力的候选者，特别是在受控药物靶向递送方面。
In this study, temperature-responsive magnetite/polymer nanoparticles were developed from iron oxide nanoparticles and poly(ethyleneimine)-modified poly(ethylene oxide)-poly(propylene oxide) -poly(ethylene oxide) (PEO-PPO-PEO) block copolymer. The particles were characterized by TEM, XRD, DLS, VSM, FTIR, and TGA. A typical product has an similar to 20 nm magnetite core and an similar to 40 nm hydrodynamic diameter with a narrow size distribution and is superparamagnetic with large saturation magnetization (51.34 emu/g) at room temperature. The most attractive feature of the nanoparticles is their temperature-responsive volume-transition property. DLS results indicated that their average hydrodynamic diameter underwent a sharp decrease from 45 to 25 nm while evaluating the temperature from 20 to 35 degrees C. The temperature-dependent evolution of the C-O stretching band in the FTIR spectra of the aqueous nanoparticles solution revealed that thermo-induced self-assembly of the immobilized block copolymers occurred on the magnetite solid surfaces, which is accompanied by a conformational change from a fully extended state to a highly coiled state of the copolymer. Consequently, the copolymer shell could act as a. temperature-controlled "gate" for the transit of guest substance. The uptake and release of both hydrophobic and hydrophilic model drugs were well controlled by switching the transient opening and closing of the polymer shell at different temperatures. A sustained release of about 3 days wag achieved in simulated human body conditions. In primary mouse experiments, drug-entrapped magnetic nanoparticles showed good biocompatibility and effective therapy for spinal cord damage. Such intelligent magnetic nanoparticles are attractive candidates for widespread biomedical applications, particularly in controlled drug-targeting delivery.