Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population.
Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population.
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ALDH2-rs671和CYP2E1-rs2031920的遗传变异导致中国人群患肝细胞癌的风险增加
DOI：
10.2147/cmar.s162105
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发表时间：
2018
影响因子：
3.3
通讯作者：
Peng T
中科院分区：
文献类型：
--
作者：
Ye X;Wang X;Shang L;Zhu G;Su H;Han C;Qin W;Li G;Peng T
目的乙醛脱氢酶2（ALDH 2）和细胞色素P450 2 E1（CYP 2 E1）与肝细胞癌（HCC）的易感性和预后有关。据报道，ALDH 2 rs671和CYP 2 E1 rs 2031920多态性与其他国家的HCC患病率相关。本研究的目的是探讨ALDH 2和CYP 2 E1与肝癌高发区广西人群肝癌易感性之间的关系。患者与方法研究队列包括300例HCC患者和292名健康对照者进行HCC易感性分析，另外20例HCC患者和10名健康对照者进行确定。采用聚合酶链反应-限制性片段长度多态性方法进行基因分型。结果ALDH 2基因突变型（G/A和A/A）与野生型（G/G）相比，在非饮酒人群中具有显著性差异（校正P=0.010，OR=0.20，95% CI=0.06-0.68）。CYP 2 E1突变基因型（C1/C2和C2/C2）与野生型（C1/C1）和相同G/G基因型相比，肝癌易感性差异有统计学意义（校正P=0.025，OR=0.42，95% CI=0.20-0.90）。饮酒对同一G/G基因型个体的肝癌易感性有影响（校正P=0.004，OR=0.32，95% CI=0.15-0.69），但与CYP 2 E1联合分析无影响（均P>0.05）。结论ALDH 2和CYP 2 E1基因突变可能是广西地区肝癌易感性的保护因素。
Objective Acetaldehyde dehydrogenase 2 (ALDH2) and cytochrome P450 2E1 (CYP2E1) have been associated with hepatocellular carcinoma (HCC) susceptibility and prognosis. The polymorphisms ALDH2 rs671 and CYP2E1 rs2031920 are reportedly correlated with the prevalence of HCC in other countries. The aim of this study was to investigate associations between ALDH2 and CYP2E1, and HCC susceptibility in a population of Guangxi, southern China, an area with a high incidence of HCC. Patients and methods The study cohort included 300 HCC cases, 292 healthy controls for HCC susceptibility analysis, and another 20 HCC cases and 10 healthy controls for ascertainment. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. Results The study results demonstrated that mutant genotypes of ALDH2 (G/A and A/A) led to significant differences in HCC susceptibility, as compared with the wild genotype (G/G) with the same C1/C1 genotype in non-drinking individuals (adjusted P=0.010, OR=0.20, 95% CI=0.06–0.68). The mutant genotypes of CYP2E1 (C1/C2 and C2/C2) brought about significant differences in HCC susceptibility, as compared with the wild genotype (C1/C1) and the same G/G genotype (adjusted P=0.025, OR=0.42, 95% CI=0.20–0.90). Drinking plays a role in HCC susceptibility in the same G/G genotype individuals (adjusted P=0.004, OR=0.32, 95% CI=0.15–0.69), but had no impact when combined with CYP2E1 for analysis (all P>0.05). Conclusion These results suggest that the mutant genotypes of ALDH2 and CYP2E1 may be protective factors for HCC susceptibility in Guangxi province, China.