SERIAL ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT-VENTRICULAR GEOMETRY AND FUNCTION AFTER LARGE MYOCARDIAL-INFARCTION IN THE RAT
SERIAL ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT-VENTRICULAR GEOMETRY AND FUNCTION AFTER LARGE MYOCARDIAL-INFARCTION IN THE RAT
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DOI：
10.1161/01.cir.89.1.345
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发表时间：
1994-01-01
期刊：
影响因子：
37.8
通讯作者：
DOUGLAS, PS
中科院分区：
文献类型：
--
作者：
LITWIN, SE;KATZ, SE;DOUGLAS, PS
背景急性心肌梗死(MI)后心力衰竭的发生可能与左心室(LV)结构和功能的改变有关。病理性左心室重构可能会加重收缩和舒张期功能障碍，因为腔内尺寸的增加往往会增加左室壁的应力。不幸的是，许多复杂的因素使患者心肌梗死后左室重构的时间进程难以清楚地确定，结构变化对功能改变的贡献尚未被充分挖掘。方法与结果在冠状动脉结扎诱导的透壁性心肌梗死前、后1周和6周，我们进行了经胸多普勒超声心动图检查，以确定左室几何和功能改变的类型、程度和时间进程。心肌梗死后1周和6周，心肌梗死组大鼠左室舒张内径大于假手术组(9.4±0.6比8.0+/-0.5和10.1+/-0.9mN，P<0.05)。
Background The development of heart failure after acute myocardial infarction (MI) may be related to alterations of left ventricular (LV) structure and function. Pathological LV remodeling may exacerbate systolic and diastolic dysfunction because increased cavity dimensions tend to increase LV wall stress. Unfortunately, many complicating factors have made it difficult to clearly define the time course of LV remodeling after myocardial infarction in patients, and the contribution of structural changes to altered function has not been fully explored.Methods and Results To determine the type, magnitude, and time course of changes in LV geometry and function, we performed transthoracic Doppler echocardiographic examinations in rats before and 1 and 6 weeks after transmural MI induced by coronary ligation. LV internal diastolic dimension was greater in infarcted than in sham-operated rats at 1 and 6 weeks after MI (9.4+/-0.6 versus 8.0+/-0.5 and 10.1+/-(0.9 versus 8.5+/-0.9 mn, respectively; P